Journal ArticleDOI
Regional variation in tensile properties and biochemical composition of the human lumbar anulus fibrosus
TLDR
The regional differences in tensile properties may result predominantly from structural rather than compositional variations and may contribute to the clinical frequency of anulus failure in the postarolateral region.Abstract:
Study DesignThe structure-function relationship of anulus fibrosus of nondegenerate lumba intervertebral discs was investigated.ObjectivesThe tensile properties and biochemical composition of single lamella specimens from human anulus librosus and their variations with anatomic region were determineread more
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Journal ArticleDOI
Mechanics and biology in intervertebral disc degeneration: a vicious circle
Pieter-Paul A. Vergroesen,Idsart Kingma,Kaj S. Emanuel,Roel J. W. Hoogendoorn,Tim J. M. Welting,B.J. van Royen,J.H. van Dieen,Theo H. Smit +7 more
TL;DR: It is argued that mechanics and biology are interconnected and amplify each other and the proposed disease model explains the comparable efficacy of very different animal models of disc degeneration, but also helps to consider the consequences of therapeutic interventions, either at the cellular, material or mechanical level.
Journal ArticleDOI
Compression-induced degeneration of the intervertebral disc: an in vivo mouse model and finite-element study.
TL;DR: In this article, an in vivo study of the biologic and biomechanical consequences of static compressive loading on the mouse tail intervertebral disc was carried out and the results indicated that maintenance of appropriate stress within the disc may be an important basis for strategies to mitigate disc degeneration and initiate disc repair.
Journal ArticleDOI
Single lamellar mechanics of the human lumbar anulus fibrosus
TL;DR: The single anulus lamella may be seen as the elementary structural unit of the anulus fibrosus, and exhibits marked anisotropy and distinct regional variation of tensile properties and fiber angles.
Journal ArticleDOI
Is the nucleus pulposus a solid or a fluid? Mechanical behaviors of the nucleus pulposus of the human intervertebral disc.
TL;DR: Whether the nucleus pulposus behaves more as a fluid or a solid in vivo depends on the rate of loading, and the authors' proposed stress‐strain law exhibited excellent agreement with the viscoelastic data.
Journal ArticleDOI
Degeneration affects the anisotropic and nonlinear behaviors of human anulus fibrosus in compression
James C. Iatridis,Lori A. Setton,Robert J. Foster,Bernard A. Rawlins,Mark Weidenbaum,Van C. Mow +5 more
TL;DR: The results suggest that the highly organized and layered network of the anulus fibrosus, which gives rise to significant anisotropic effects in tension, does not play a major role in contributing to the magnitude of compressive stiffness or the mechanisms of fluid flow of theAnulus in the confined compression configuration.
Related Papers (5)
Investigation of the laminate structure of lumbar disc anulus fibrosus.
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