Mechanics and biology in intervertebral disc degeneration: a vicious circle
Pieter-Paul A. Vergroesen,Idsart Kingma,Kaj S. Emanuel,Roel J. W. Hoogendoorn,Tim J. M. Welting,B.J. van Royen,J.H. van Dieen,Theo H. Smit +7 more
TLDR
It is argued that mechanics and biology are interconnected and amplify each other and the proposed disease model explains the comparable efficacy of very different animal models of disc degeneration, but also helps to consider the consequences of therapeutic interventions, either at the cellular, material or mechanical level.About:
This article is published in Osteoarthritis and Cartilage.The article was published on 2015-07-01 and is currently open access. It has received 528 citations till now. The article focuses on the topics: Degeneration (medical).read more
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Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration.
TL;DR: This review deciphers the senescence mechanism of IVD degeneration (IVDD) by interpreting how aging coordinates with age-related, microenvironment-derived stresses in promoting disc cellsenescence and accelerating IVDD.
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Disc in flames: Roles of TNF-α and IL-1β in intervertebral disc degeneration.
TL;DR: The contributions of TNF-α and IL-1β to changes seen during disc degeneration at both cellular and tissue level are described, as well as new evidence suggesting a link between infection of the spine and low back pain, and the emerging therapeutic modalities aimed at combating these processes.
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Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo
Zhiwei Liao,Rongjin Luo,Gaocai Li,Yu Song,Shengfeng Zhan,Kangcheng Zhao,Wenbin Hua,Yukun Zhang,Xinghuo Wu,Cao Yang +9 more
TL;DR: This work is the first to demonstrate that MSC-exos could modulate ER stress-induced apoptosis during AGEs-associated IVD degeneration, and highlight the therapeutic effects of exosomes in preventing IDD progression.
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A Review of Animal Models of Intervertebral Disc Degeneration: Pathophysiology, Regeneration, and Translation to the Clinic
TL;DR: The role of animal models of disc degeneration in translational research leading to clinical trials of novel cellular therapies is explored and the purpose of such animal models is to further understanding and, ultimately, improve treatment of Disc degeneration.
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Mitophagy in degenerative joint diseases
TL;DR: The potential of targeting mitophagy for the treatment of degenerative joint diseases is highlighted and strategies by the regulation ofMitophagy exert beneficial effects in the pre-clinical experiments.
References
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Journal Article
Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010 (vol 380, pg 2197, 2012)
TL;DR: In this article, a comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study, and the authors aimed to calculate disease burden globally and for 21 regions for 1990, 2005, and 2010 with methods to enable meaningful comparisons over time.
Journal ArticleDOI
Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
Christopher J L Murray,Theo Vos,Rafael Lozano,Mohsen Naghavi,Abraham D. Flaxman,Catherine Michaud,Majid Ezzati,Kenji Shibuya,Joshua A. Salomon,Safa Abdalla,Victor Aboyans,Jerry Abraham,Ilana N. Ackerman,Rakesh Aggarwal,Stephanie Y. Ahn,Mohammed K. Ali,Mohammad A. AlMazroa,Miriam Alvarado,H. Ross Anderson,Laurie M. Anderson,Kathryn G. Andrews,Charles Atkinson,Larry M. Baddour,Adil N. Bahalim,Suzanne Barker-Collo,Lope H Barrero,David Bartels,María-Gloria Basáñez,Amanda J Baxter,Michelle L. Bell,Emelia J. Benjamin,Derrick A Bennett,Eduardo Bernabé,Kavi Bhalla,Bishal Bhandari,Boris Bikbov,Aref A. Bin Abdulhak,Gretchen L. Birbeck,James A. Black,Hannah Blencowe,Jed D. Blore,Fiona M. Blyth,Ian Bolliger,Audrey Bonaventure,Soufiane Boufous,Rupert R A Bourne,Michel Boussinesq,Tasanee Braithwaite,Carol Brayne,Lisa Bridgett,Simon Brooker,Peter Brooks,Traolach S. Brugha,Claire Bryan-Hancock,Chiara Bucello,Rachelle Buchbinder,Geoffrey Buckle,Christine M. Budke,Michael Burch,Peter Burney,Roy Burstein,Bianca Calabria,Benjamin L. Campbell,Charles E. Canter,Hélène Carabin,Jonathan R. Carapetis,Loreto Carmona,Claudia Cella,Fiona J Charlson,Honglei Chen,Andrew T. A. Cheng,David Chou,Sumeet S. Chugh,Luc E. Coffeng,Steven D. Colan,Samantha M. Colquhoun,K. Ellicott Colson,John R. Condon,Myles Connor,Myles Connor,Myles Connor,Leslie T. Cooper,Matthew A. Corriere,Monica Cortinovis,Karen Courville De Vaccaro,William G. Couser,Benjamin C Cowie,Michael H. Criqui,Marita Cross,Kaustubh Dabhadkar,Manu Dahiya,Nabila Dahodwala,James Damsere-Derry,Goodarz Danaei,Adrian Davis,Diego De Leo,Louisa Degenhardt,Louisa Degenhardt,Robert P. Dellavalle,Allyne Delossantos,Julie O. Denenberg,Sarah Derrett,Don C. Des Jarlais,Samath D Dharmaratne,Samath D Dharmaratne,Mukesh Dherani,Cesar Diaz-Torne,Helen Dolk,E. Ray Dorsey,Tim Driscoll,Herbert C. Duber,Beth E. Ebel,Karen Edmond,Alexis Elbaz,S. Ali,Holly E. Erskine,Patricia J. Erwin,Patricia Espindola,Stalin E. Ewoigbokhan,Farshad Farzadfar,Valery L. Feigin,David T. Felson,Alize J. Ferrari,Cleusa P. Ferri,Eric M. Fèvre,Mariel M. Finucane,Seth Flaxman,Louise Flood,Kyle J Foreman,Mohammad H. Forouzanfar,F.G.R. Fowkes,Marlene Fransen,Michael Freeman,Belinda J. Gabbe,Sherine E. Gabriel,Emmanuela Gakidou,Hammad A. Ganatra,Bianca Garcia,Flavio Gaspari,Richard F. Gillum,Gerhard Gmel,Diego Gonzalez-Medina,Richard A. Gosselin,Rebecca Grainger,Bridget F. Grant,Justina Groeger,Francis Guillemin,David Gunnell,R Gupta,Juanita A. Haagsma,Holly Hagan,Yara A. Halasa,Wayne Hall,Diana Haring,Josep Maria Haro,James Harrison,Rasmus Havmoeller,Rasmus Havmoeller,Roderick J. Hay,Hideki Higashi,Christopher Hill,Bruno Hoen,Howard J. Hoffman,Peter J. Hotez,Damian G Hoy,John J Huang,Sydney E. Ibeanusi,Kathryn H. Jacobsen,Spencer L. James,Deborah Jarvis,Rashmi Jasrasaria,Sudha Jayaraman,Nicole E. Johns,Jost B. Jonas,Ganesan Karthikeyan,Nicholas J Kassebaum,Norito Kawakami,Andre Keren,Jon Paul Khoo,Charles H. King,Lisa M. Knowlton,Olive Kobusingye,Olive Kobusingye,Adofo Koranteng,Rita Krishnamurthi,Francine Laden,Ratilal Lalloo,Laura L Laslett,Tim Lathlean,Janet L Leasher,Yong Yi Lee,James Leigh,Daphna Levinson,Stephen S Lim,Elizabeth S Limb,John K Lin,Michael S Lipnick,Steven E. Lipshultz,Wei Liu,Maria Loane,Summer Lockett Ohno,Ronan A Lyons,Jacqueline Mabweijano,Michael F. MacIntyre,Reza Malekzadeh,Leslie Mallinger,Sivabalan Manivannan,Wagner Marcenes,Lyn March,David J. Margolis,Guy B. Marks,Robin Marks,Akira Matsumori,Richard Matzopoulos,Richard Matzopoulos,Bongani M. Mayosi,John H. McAnulty,Mary M. McDermott,Neil McGill,John J. McGrath,María Elena Medina-Mora,Michele Meltzer,Ziad A. Memish,George A. Mensah,Tony R. Merriman,Ana-Claire Meyer,Valeria Miglioli,Matthew J. Miller,Ted R. Miller,Philip B. Mitchell,Charles Mock,Ana Olga Mocumbi,Terrie E. Moffitt,Ali A. Mokdad,Lorenzo Monasta,Marcella Montico,Maziar Moradi-Lakeh,Andrew E. Moran,Lidia Morawska,Rintaro Mori,Michele E. Murdoch,Michael K Mwaniki,Kovin Naidoo,M. Nathan Nair,Luigi Naldi,K.M. Venkat Narayan,Paul K. Nelson,Robert G. Nelson,Michael C. Nevitt,Charles R. Newton,Sandra Nolte,Paul Norman,Rosana E. Norman,Martin O'Donnell,Simon J. O’Hanlon,Casey Olives,Saad B. Omer,Katrina F Ortblad,Richard H. Osborne,Doruk Ozgediz,Andrew Page,Bishnu Pahari,Jeyaraj D Pandian,Andrea Panozo Rivero,Scott B. Patten,Neil Pearce,Rogelio Perez Padilla,Fernando Perez-Ruiz,Norberto Perico,Konrad Pesudovs,David Phillips,Michael Phillips,Kelsey Pierce,Sébastien D. S. Pion,Guilherme V. Polanczyk,Suzanne Polinder,C. Arden Pope,Svetlana Popova,Esteban Porrini,Farshad Pourmalek,Martin Prince,Rachel L. Pullan,Kapa D. Ramaiah,Dharani Ranganathan,Homie Razavi,Mathilda Regan,Jürgen Rehm,David B. Rein,G. Remuzzi,Kathryn Richardson,Frederick P. Rivara,Thomas Roberts,Carolyn Robinson,Felipe Rodriguez De Leòn,Luca Ronfani,Robin Room,Robin Room,Lisa C. Rosenfeld,Lesley Rushton,Ralph L. Sacco,Sukanta Saha,Uchechukwu Sampson,Lidia Sanchez-Riera,Ella Sanman,David C. Schwebel,James Scott,Maria Segui-Gomez,Saeid Shahraz,Donald S. Shepard,Hwashin Shin,Rupak Shivakoti,Donald H. Silberberg,David Singh,Gitanjali M Singh,Jasvinder A. Singh,Jessica Singleton,David A. Sleet,Karen Sliwa,Emma Smith,Jennifer L. Smith,Nicolas J. C. Stapelberg,Andrew C Steer,Timothy J. Steiner,Wilma A. Stolk,Lars Jacob Stovner,Christopher R. Sudfeld,Sana Syed,Giorgio Tamburlini,Mohammad Tavakkoli,Hugh R. Taylor,Jennifer A. Taylor,William J. Taylor,Bernadette Thomas,W. Murray Thomson,George D. Thurston,Imad M. Tleyjeh,Marcello Tonelli,Jeffrey A. Towbin,Thomas Truelsen,Miltiadis K. Tsilimbaris,Clotilde Ubeda,Eduardo A. Undurraga,Marieke J. van der Werf,Jim van Os,Monica S. Vavilala,Narayanaswamy Venketasubramanian,Mengru Wang,Wenzhi Wang,Kerrianne Watt,David J. Weatherall,Martin A. Weinstock,Robert G. Weintraub,Marc G. Weisskopf,Myrna M. Weissman,Richard A. White,Harvey Whiteford,Natasha Wiebe,Steven T. Wiersma,James D. Wilkinson,Hywel C Williams,Sean R.M. Williams,Emma Witt,Frederick Wolfe,Anthony D. Woolf,Sarah Wulf,Pon Hsiu Yeh,Anita K. M. Zaidi,Zhi Jie Zheng,David Zonies,Alan D. Lopez +369 more
TL;DR: The results for 1990 and 2010 supersede all previously published Global Burden of Disease results and highlight the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account.
Journal ArticleDOI
Genetic studies of body mass index yield new insights for obesity biology
Glgc,Icbp,Magic Investigators +2 more
TL;DR: A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility.
Journal ArticleDOI
Magnetic resonance classification of lumbar intervertebral disc degeneration.
TL;DR: Disc degeneration can be graded reliably on routine T2-weighted magnetic resonance images using the grading system and algorithm presented in this investigation.