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Regulation of Axon Formation by Clonal Lines of a Neural Tumor

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TLDR
Clonal lines of neuroblastoma cells were found to extend or retract axons depending upon the concentration of serum, suggesting that neurite formation is dependent upon the assembly of microtubules or neurofilaments from preformed protein subunits.
Abstract
Clonal lines of neuroblastoma cells were found to extend or retract axons depending upon the concentration of serum. Neurite extension was not inhibited by cycloheximide but was sensitive to colchicine or vinblastine, suggesting that neurite formation is dependent upon the assembly of microtubules or neurofilaments from preformed protein subunits.

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Journal ArticleDOI

Microfilaments in Cellular and Developmental Processes

TL;DR: The overall conclusion is that a broad spectrum of cellular and developmental processes are caused by contractile apparatuses that have at least the common feature of being sensitive to cytochalasin.
Journal ArticleDOI

Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide.

TL;DR: This action of dimethyl sulfoxide, which was reversible, may represent the derepression of leukemic cells to permit their maturation in cloned line of murine virus-induced erythroleukemia.
Journal ArticleDOI

Clonal cell lines from the rat central nervous system

TL;DR: Five neuronal and a large collection of putative glial cell lines from the rat central nervous system have been established in clonal cell culture and partially characterised and shed new light on the distribution of neurotransmitter synthesis and brain-specific antigens among nerve and glia.
Journal ArticleDOI

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

TL;DR: RhoA is essential for receptor-mediated force generation and ensuing neurite retraction in N1E-115 and PC12 cells, and that inactivation of RhoA by ADP-ribosylation abolishes actomyosin contractility and promotes neurite outgrowth.
Journal ArticleDOI

Tau protein binds to microtubules through a flexible array of distributed weak sites.

TL;DR: A collection of tau protein fragments synthesized and studied their binding properties suggest tauprotein can assume multiple conformations and can pivot and perhaps migrate on the surface of the microtubule.
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