Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide.
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This action of dimethyl sulfoxide, which was reversible, may represent the derepression of leukemic cells to permit their maturation in cloned line of murine virus-induced erythroleukemia.Abstract:Â
Cells of a cloned line of murine virus-induced erythroleukemia were stimulated to differentiate along the erythroid pathway by dimethyl sulfoxide at concentrations that did not inhibit growth. A rise in the number of benzidine-positive normoblasts was accompanied by increased synthesis of heme and hemoglobin and a decrease in the malignancy of the cells. This action of dimethyl sulfoxide, which was reversible, may represent the derepression of leukemic cells to permit their maturation.read more
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Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid.
TL;DR: This study suggests that retinoids could provide a therapeutic tool in the treatment of acute myeloid leukemia, and indicates thatretinoids, in addition to their well-characterized involvement in epithelial cell differentiation, may also be involved in the differentiation of certain hematopoietic cells.
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Histone deacetylases and cancer: causes and therapies.
Paul A. Marks,Richard A. Rifkind,Victoria M. Richon,Ronald Breslow,Thomas E. Miller,William Kevin Kelly +5 more
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Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds.
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The induction of differentiation in teratocarcinoma stem cells by retinoic acid
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Histone Deacetylase Inhibitors: Inducers of Differentiation or Apoptosis of Transformed Cells
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References
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Multipotentiality of Single Embryonal Carcinoma Cells
TL;DR: The capacity of single embryonal carcinoma cells to differentiate into benign tissues supports neither the dogma of the irreversibility of the malignant transformation nor the somatic cell mutation theory of cancer.
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Definition of a Continuous Human Cell Line Derived from Neuroblastoma
TL;DR: A continuous hyperdiploid human cell line, IMR-32, was derived from neuroblastoma tissue and proved a relatively poor host for virus replication, particularly for representative viruses of two of the human enterovirus groups.
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Regulation of Axon Formation by Clonal Lines of a Neural Tumor
TL;DR: Clonal lines of neuroblastoma cells were found to extend or retract axons depending upon the concentration of serum, suggesting that neurite formation is dependent upon the assembly of microtubules or neurofilaments from preformed protein subunits.
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Electron Microscope Studies of Ribosomal Clusters Synthesizing Hemoglobin.
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In vitro differentiation of a mouse neuroblastoma.
TL;DR: Mouse tumor C1300 has been established in tissue culture and cell attachment can induce morphological differentiation from an anaplastic round cell to a cell which has many properties of a mature neuron.