Regulation of IP3 receptors by cyclic AMP
TLDR
In this paper, the effects of cAMP on inositol 1,4,5-trisphosphate receptors (IP3Rs) are briefly reviewed, showing that cAMP-dependent protein kinase (PKA)-independent modulation of IP3Rs is delivered to them within signalling junctions that include type 6 adenylyl cyclase.About:
This article is published in Cell Calcium.The article was published on 2017-05-01 and is currently open access. It has received 69 citations till now. The article focuses on the topics: Protein kinase A & Adenylyl cyclase.read more
Citations
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Journal ArticleDOI
Structure and Function of IP3 Receptors
David L. Prole,Colin W. Taylor +1 more
TL;DR: This work has shown that some IP3 clusters, namely those parked alongside the ER-plasma membrane junctions where SOCE occurs, are licensed to respond, and the location of these licensed IP3Rs may allow them to selectively regulate SOCE.
Journal ArticleDOI
Calcium-release channels: structure and function of IP3 receptors and ryanodine receptors.
Kellie A. Woll,Filip Van Petegem +1 more
TL;DR: In this article, the two members, ryanodine receptors (RyRs) and inositol-1,4,5-trace ratio (INOS), were identified as the Ca2+-release channels.
Journal ArticleDOI
Calcium-release channels: structure and function of IP<sub>3</sub> receptors and ryanodine receptors
TL;DR: The structure of Ca2+-release channels has been extensively studied using electron microscopic methods as discussed by the authors , with current structures reaching near 3 Å, and the available structures have provided many new mechanistic insights into the binding of auxiliary proteins and small molecules, how these can regulate channel opening and the mechanisms of disease-associated mutations.
Book ChapterDOI
New Insights in the IP 3 Receptor and Its Regulation
Jan B. Parys,Tim Vervliet +1 more
TL;DR: A special focus of this review will be directed towards the regulation of the IP3R by protein-protein interaction, especially the protein family formed by calmodulin and related Ca2+-binding proteins and the pro- and anti-apoptotic/autophagic Bcl-2-family members.
Journal ArticleDOI
Simulation of calcium signaling in fine astrocytic processes: Effect of spatial properties on spontaneous activity.
TL;DR: This model is the first model suited to investigate calcium dynamics in fine astrocytic processes and to propose plausible mechanisms responsible for their variability and is both spatially explicit and particle-based.
References
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Voltage-Gated Calcium Channels
TL;DR: The molecular relationships and physiological functions of these voltage-gated Ca(2+) channel proteins are presented and information on their molecular, genetic, physiological, and pharmacological properties is provided.
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Cell Communication, Calcium Ion, and Cyclic Adenosine Monophosphate
TL;DR: The changes in membrane potentials indicate the likelihood of widespread changes in the properties of the cell membrane, for example, changes in Na+ and K+ transport and distribution.
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Protein molecules as computational elements in living cells
TL;DR: Many proteins in living cells appear to have as their primary function the transfer and processing of information, rather than the chemical transformation of metabolic intermediates or the building of cellular structures.
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Overview of PDEs and Their Regulation
Kenji Omori,Jun Kotera +1 more
TL;DR: Multiple PDEs function as a particular modulator of each cardiovascular function and regulate physiological homeostasis.