Journal ArticleDOI
Relationship between acetylcholine content and release in the cat's cerebral cortex.
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Cortical acetylcholine (ACh) release and content were measured in non-anesthetized pretrigeminally sectioned or in Dial-ansthetized cats.Abstract:
Cortical acetylcholine (ACh) release and content were measured in non-anesthetized pretrigeminally sectioned or in Dial-anesthetized cats. In 28 pretrigerninally sectioned cats a very highly significant negative correlation between ACh content and output was found. In the same preparations, 15 mg/kg pentobarbital or electrolytic lesion in the rostral midbrain decreased ACh output and increased content. Atropine (1 mg/kg i.v. or 1 μg/ml topically) increased ACh output fourfold without significantly altering content. A larger dose of atropine (25 mg/kg i.v.) increased output ninefold and decreased ACh content. In Dial-anesthetized preparations, picrotoxin-induced ACh release was accompanied by a decrease in ACh content. Pretreatment with atropine in the same preparation resulted in an enhanced effect of picrotoxin on both output and content while atropine alone (1 mg/kg i.v.) raised ACh output without decreasing content. In pretrigerminally sectioned non-anesthetized preparations, hemicholinium-3 (HC-3) did...read more
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Inhibitory influence of the nigrostriatal dopamine system on the striatal cholinergic neurons in the rat.
TL;DR: It is postulated that a long term adaptation of the striatal cholinergic neurons may have occurred after complete degeneration of the nigrostriatal DA pathway, and changes in ACh levels, which have been shown to be a good index of dopamine levels, argue against an inhibitory dopaminergic influence on the striato-cholinergic system.
Journal ArticleDOI
Phencyclidine-induced rotational behavior in rats with nigrostriatal lesions and its modulation by dopaminergic and cholinergic agents.
TL;DR: PCP may induce rotational behavior by potentiating dopaminergic transmission, by blocking cholinergic activity, or both; both of these effects have been demonstrated to be important in the generation of circling behavior in rats with nigrostriatal lesions.
Journal ArticleDOI
The output per stimulus of acetylcholine from cerebral cortical slices in the presence or absence of cholinesterase inhibition.
TL;DR: Results suggest that under physiological conditions, i.e. in the absence of an anticholinesterase, the release of ACh per stimulus decreases with increasing frequency of stimulation and that this decrease is due to a lag in the mobilization of stored ACh rather than in the synthesis of new ACh.
Journal ArticleDOI
The role of the septal nuclei in the release of acetylcholine from the rabbit cerebral cortex and dorsal hippocampus and the effect of atropine
TL;DR: The data indicate that the septum is an essential pathway for cholinergic fibres ascending to the cerebral cortex and hippocampus and demonstrate that theseptal cholin allergic fibres must be intact and active for atropine to increase ACh release from their terminals.
Journal ArticleDOI
Choline administration: modification of the central actions of atropine.
TL;DR: Findings suggest that alterations in acetylcholine precursor availability may modify the effects of centrally active anticholinergic agents.
References
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Journal ArticleDOI
The spontaneous and evoked release of acetylcholine from the cerebral cortex
TL;DR: It has been found that excitation of the cortex, either through sensory nerves or by direct electrical stimulation, increases the ACh output and the most important step in the identification of cholinergic transmission has been the demonstration of the release of ACh during stimulation of the appropriate nerve.