Journal ArticleDOI
Relative importance of alpha and beta adrenergic receptors during resuscitation.
TLDR
Results suggest that, initially, alpha receptor stimulation with concomitant diastolic pressure elevation is more important to the success of resuscitation than beta receptor stimulation.Abstract:
Successful resuscitation from cardiac arrest in the asphyxiated dog model has been ascribed to the use of artificial ventilation, closed chest cardiac massage, and administration of a vasopressor. Controversy remains over whether the most commonly employed vasopressor, epinephrine, exerts its effects primarily by elevating diastolic pressure and reestablishing coronary flow, or by exciting cardiac pacemaker cells and enhancing myocardial contractility. To observe pure alpha and beta adrenergic receptor influences during resuscitation, three groups (alpha-blocked, beta-blocked, unblocked) of dogs were studied. beta-blocked dogs resuscitated with phenylephrine and unblocked dogs resuscitated with epinephrine experienced 100% successful resumption of spontaneous circulation after 5 min of asphyxia-induced arrest. Only 27% of alpha-blocked animals resuscitated with isoproterenol were successfully revived. The appearance of the ECG during cardiac arrest and resuscitation could in no way be used to predict the outcome of resuscitation attempts. Results suggest that, initially, alpha receptor stimulation with concomitant diastolic pressure elevation is more important to the success of resuscitation than beta receptor stimulation.read more
Citations
More filters
Journal ArticleDOI
Part 8: Adult Advanced Cardiovascular Life Support 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
Robert W. Neumar,Charles W. Otto,Mark S. Link,Steven L. Kronick,Michael Shuster,Clifton W. Callaway,Peter J. Kudenchuk,Joseph P. Ornato,Bryan McNally,Scott M. Silvers,Rod S. Passman,Roger D. White,Erik P. Hess,Wanchun Tang,Daniel Davis,Elizabeth Sinz,Laurie J. Morrison +16 more
TL;DR: The goal of therapy for bradycardia or tachycardia is to rapidly identify and treat patients who are hemodynamically unstable or symptomatic due to the arrhythmia.
Journal ArticleDOI
Coronary perfusion pressure and the return of spontaneous circulation in human cardiopulmonary resuscitation.
Norman A. Paradis,Gerard B. Martin,Emanuel P. Rivers,Mark G. Goetting,Timothy J. Appleton,Marcia Feingold,Richard M. Nowak +6 more
TL;DR: Of variables measured, maximal CPP was most predictive of ROSC, and all CPP measurements were more predictive than was aortic pressure alone, substantiates animal data that indicate the importance of CPP during cardiopulmonary resuscitation.
Journal ArticleDOI
Mechanisms by which epinephrine augments cerebral and myocardial perfusion during cardiopulmonary resuscitation in dogs.
John R. Michael,Alan D. Guerci,Raymond C. Koehler,A. Y. Shi,Joshua E. Tsitlik,Nisha Chandra,E. Niedermeyer,M. C. Rogers,Richard J. Traystman,Myron L. Weisfeldt +9 more
TL;DR: The hypothesis was that epinephrine would improve myocardial and cerebral blood flow by preventing collapse of intrathoracic arteries and by vasoconstricting other vascular beds, thereby increasing perfusion pressures and improving electroencephalographic activity and restoration of spontaneous circulation.
Journal ArticleDOI
Higher Survival Rates Among Younger Patients After Pediatric Intensive Care Unit Cardiac Arrests
Peter A. Meaney,Vinay M. Nadkarni,E. Francis Cook,Marcia A. Testa,Mark A. Helfaer,William Kaye,G. Luke Larkin,Robert A. Berg +7 more
TL;DR: Newborns and infants demonstrated double and triple the odds of surviving to hospital discharge from a cardiac arrest in an intensive care setting when compared with older children when potential confounders were controlled.
Journal ArticleDOI
Resuscitation in Europe: a Tale of five European Regions
TL;DR: Many EMS systems in Europe show extremely good results in terms of survival after an out-of-hospital cardiac arrest, and some of the results should be interpreted with caution since they were based on relatively small sample sizes.