Journal ArticleDOI
Removal and utilization of ketone bodies by the brain of newborn puppies.
J. J. Spitzer,J. T. Weng +1 more
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It is concluded that the removal and utilization of ketones is of physiological importance in the brain of newborn animals.Abstract:
The removal of circulating ketone bodies by the brain was investigated in 0- to 8-day-old puppies under pentobarbital anaesthesia. Of the arterial acetoacetate (AcAc) and β-hydroxybutyrate (βOHB), 24 and 30 per cent, respectively, were removed by the brain. There was a direct correlation between the arterial concentrations of either AcAc or βOHB and the A-V difference of the respective ketone body across the brain. When a continuous infusion of Na-dl-3-hydroxybutyrate [3-14T] was administered for more than 2 h, labelling of both phospholipids and free cholesterol was consistently observed in all six areas of the brain that were sampled. We conclude that the removal and utilization of ketones is of physiological importance in the brain of newborn animals.read more
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Carbohydrate and energy metabolism in perinatal rat brain: relation to survival in anoxia.
TL;DR: It is concluded that in post‐natal animals survival in anoxia and cerebral energy consumption are inversely, and nearly quantitatively, related, however, the reduced cerebral energy requirement cannot entirely account for the greater anoxic resistance of fetuses.
Journal ArticleDOI
Energy metabolism in mammalian brain during development.
TL;DR: This review attempts to link the plethora of information on the maturation of the central nervous system with the ontogeny of ATP metabolism, placing special emphasis on variations that occur during development in different brain regions and across the mammalian species.
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Cerebral Metabolic Adaptation and Ketone Metabolism after Brain Injury
TL;DR: The evidence presented supports the following findings: (1) there is an inverse relationship between age and the brain's capacity for ketone metabolism that continues well after weaning, and (2) neuroprotective potentials of ketone administration have been shown for neurodegenerative conditions, epilepsy, hypoxia/ischemia, and traumatic brain injury.
Journal ArticleDOI
Hypoglycemia in newborn infants: Features associated with adverse outcomes.
Paul J. Rozance,William W. Hay +1 more
TL;DR: There is inadequate information in the literature to define any one value of glucose below which irreparable hypoglycemic injury to the central nervous system occurs, at any one time or for any defined period of time, in a population of infants or in any given infant.
Journal ArticleDOI
Glucose metabolism in the developing brain
TL;DR: Gl glucose plays a critical role in the developing brain, not only as the primary substrate for energy production but also to allow for normal biosynthetic processes to proceed.
References
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Journal ArticleDOI
A simple efficient liquid scintillator for counting aqueous solutions in a liquid scintillation counter
TL;DR: A modification of the naphthalene-dioxane-PPO liquid scintillator has been described which will allow up to 3.0 ml of an aqueous solution to be counted as mentioned in this paper.
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Brain Metabolism during Fasting
TL;DR: Catheterization of cerebral vessels in three obese patients undergoing 5-6 wk of starvation demonstrated that beta-hydroxybutyrate and acetoacetate replaced glucose as the predominant fuel for brain metabolism.
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Enzymic determination of d(−)-β-hydroxybutyric acid and acetoacetic acid in blood
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Ketone-body utilization by adult and suckling rat brain in vivo
TL;DR: The results indicate that ketone bodies are major metabolic fuels of the brain of the suckling rat under normal conditions and are independent of the nutritional state.