Journal ArticleDOI
Research integrity and pharmaceutical industry sponsorship.
TLDR
Trial registration, transparency and less reliance on industry trials are essential to reduce the number of trials and improve the quality of trials.Abstract:
Trial registration, transparency and less reliance on industry trials are essential.read more
Citations
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Journal ArticleDOI
Closing the gaps.
TL;DR: It is argued that science is not intrinsically competitive but that a progressive blurring of the boundaries between science and commerce has generated a destructive climate of secrecy which is contrary to the public interest and common good.
Journal ArticleDOI
Metabias: a challenge for comparative effectiveness research.
Steven N. Goodman,Kay Dickersin +1 more
TL;DR: This issue's study in this issue raises the specter of a new metabias that is similar to EMT, which poses unique challenges for comparative effectiveness research and evidence-based healthcare.
Dissertation
Clinical trial information: developing an effective model of dissemination and a framework to improve transparency
TL;DR: A conceptual model was constructed outlining the structure of information generation throughout the clinical research process and identified that clinical trial information is very complex, scattered across many resources and many factors affect how, where and what clinicaltrial information is disseminated.
Journal Article
Reviewing the evidence for using continuous subcutaneous metoclopramide and ondansetron to treat nausea & vomiting during pregnancy.
TL;DR: Randomized, controlled trials of sufficient power are necessary before long-term continuous subcutaneous metoclopramide or ondansetron can be used on a widespread basis to treat nausea and vomiting during pregnancy.
Journal ArticleDOI
Implementing a research governance framework for clinical and public health research
TL;DR: An evaluation of the effect of audit on researchers found that the process was well accepted, and the need for participant confidentiality, privacy and data security was found to be understood, and adhered to widely by all researchers.
References
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Journal ArticleDOI
Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT)
Curt D. Furberg,Jackson T. Wright,Barry R. Davis,Jeffrey A. Cutler,Michael H. Alderman,Henry R. Black,William C. Cushman,Richard H. Grimm,L. Julian Haywood,Frans H. H. Leenen,Suzanne Oparil,Jeffrey L. Probstfield,Paul K. Whelton,Chuke Nwachuku,David Gordon,Michael A. Proschan,Paula Einhom,Charles E. Ford,Linda B. Piller,I. Kay Dunn,David C. Goff,Sara L. Pressel,Judy Bettencourt,Barbara DeLeon,Lara M. Simpson,Joe Blanton,Therese S. Geraci,Sandra M. Walsh,Christine Nelson,Mahboob Rahman,Anne Juratovac,Robert Pospisil,Lillian Carroll,Sheila Sullivan,Jeanne Russo,Gail Barone,Rudy Christian,Sharon Feldman,Tracy Lucente,David A. Calhoun,Kim Jenkins,Peggy McDowell,Janice Johnson,Connie Kingry,Juan Alzate,Karen L. Margolis,Leslie Ann Holland-Klemme,Brenda Jaeger,Jeff D. Williamson,Gail T. Louis,Pamela Ragusa,Angela Williard,R. L Sue Ferguson,Joanna Tanner,John H. Eckfeldt,Richard S. Crow,John Pelosi +56 more
TL;DR: Thiazide-type diuretics are superior in preventing 1 or more major forms of CVD and are less expensive and should be preferred for first-step antihypertensive therapy.
Journal ArticleDOI
Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles.
TL;DR: The reporting of trial outcomes is not only frequently incomplete but also biased and inconsistent with protocols and Published articles, as well as reviews that incorporate them, may therefore be unreliable and overestimate the benefits of an intervention.
Journal ArticleDOI
Scope and Impact of Financial Conflicts of Interest in Biomedical Research: A Systematic Review
TL;DR: In this article, the authors reviewed original, quantitative studies on the extent, impact, and management of financial conflicts of interest in biomedical research and concluded that financial relationships among industry, scientific investigators, and academic institutions are widespread.
Journal ArticleDOI
Risk of cardiovascular events and rofecoxib: cumulative meta-analysis
Peter Jüni,Linda Nartey,Stephan Reichenbach,Stephan Reichenbach,Rebekka Sterchi,Paul Dieppe,Matthias Egger,Matthias Egger +7 more
TL;DR: The findings indicate that rofecoxib should have been withdrawn several years earlier and the reasons why manufacturer and drug licensing authorities did not continuously monitor and summarise the accumulating evidence need to be clarified.
Journal ArticleDOI
Association of funding and conclusions in randomized drug trials: a reflection of treatment effect or adverse events?
TL;DR: Conclusions in trials funded by for-profit organizations may be more positive due to biased interpretation of trial results, and readers should carefully evaluate whether conclusions in randomized trials are supported by data.