Journal ArticleDOI
Results of a two year chronic toxicity study with hexachlorobutadiene in rats.
R.J. Kociba,D. G. Keyes,G. C. Jersey,J. J. Ballard,D.A. Dittenber,J.F. Quast,C.E. Wade,Charles G Humiston,B.A. Schwetz +8 more
TLDR
Lifetime ingestion by rats of 0.2 mg/kg/day of hexachlorobutadiene caused no discernible ill effects, but slight degrees of primarily renal toxicity occurred with 2 mg/ kg/day; 20 mg/ kilograms/day caused multiple toxic effects, including renal tubular neoplasms.Abstract:
Lifetime ingestion by rats of 0.2 mg/kg/day of hexachlorobutadiene caused no discernible ill effects. Slight degrees of primarily renal toxicity occurred with 2 mg/kg/day; 20 mg/kg/day caused multiple toxic effects, including renal tubular neoplasmsread more
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Journal ArticleDOI
A New Method for Determining Allowable Daily Intakes
TL;DR: This paper proposes and illustrates the use of a "benchmark dose" (BD) as an alternative to a NOEL, a statistical lower confidence limit to a dose producing some predetermined increase in response rate such as 0.01 or 0.1.
Journal ArticleDOI
A carcinogenic potency database of the standardized results of animal bioassays
Lois Swirsky Gold,C B Sawyer,Renae Magaw,G M Backman,M de Veciana,R Levinson,N K Hooper,W R Havender,Leslie R. Bernstein,Richard Peto +9 more
TL;DR: The Carcinogenic Potency Database is presented, which includes results of about 3000 long-term, chronic experiments of 770 test compounds, which provides quantitative information about negative tests and readily permits comparisons of carcinogenic potency and many other aspects of cancer tests.
Journal ArticleDOI
A new method for determining allowable daily intakes.
Journal ArticleDOI
Glutathione Conjugate-Mediated Toxicities
Terrence J. Monks,M. W. Anders,Wolfgang Dekant,J. L. Stevens,Serrine S. Lau,P.J. van Bladeren +5 more
TL;DR: In this paper, the most recent advances in our knowledge of the mechanism(s) by which xenobiotic conjugations with GSH can result in toxicity are described, as well as the mechanism by which GSH conjugation results in toxicity.
Journal ArticleDOI
Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites.
TL;DR: The material presented in this review deals with the hypothesis that the nephrotoxicity of certain halogenated alkanes and alkenes is associated with hepatic biosynthesis of glutathione S-conjugates, which are further metabolized to the corresponding cysteine S- Conjugates.
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