Journal ArticleDOI
Retrogenetic Expression: the Reappearance of Embryonal Antigens in Cancer Cells
TLDR
These findings stimulated a study of the possible universal appearance of embryonic antigens in cancer tissues, which has been detected in colonic, hepatic and lung cancers.Abstract:
VARIOUS reports of embryonal antigens in extracts of tumour tissues have appeared since 1932 (refs. 1–9). Such antigens, absent from homologous normal tissues, have been detected in colonic6, hepatic7 and lung cancers8. These findings stimulated a study of the possible universal appearance of embryonic antigens in cancer tissues.read more
Citations
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Book ChapterDOI
The interactions of lectins with animal cell surfaces.
TL;DR: This chapter discusses the interactions of lectins with animal cell surfaces, which have proven to be quite useful for clinical blood typing and structural studies of blood group substances, in analysis of the surface structure of normal and tumor cells, and so on.
Book ChapterDOI
The sequential analysis of cancer development.
Emmanuel Farber,Ross Cameron +1 more
TL;DR: This chapter reviews the sequence of cellular and other changes during cancer development in selected sites in experimental animals and in humans and highlights the similarities and differences among the carcinogenic processes.
Journal ArticleDOI
Glycoproteins of Cell Surfaces A COMPARATIVE STUDY OF THREE DIFFERENT CELL SURFACES OF THE RAT
TL;DR: Each membrane is found to have an identifiable glycoprotein subunit pattern composed of at least 6 to 11 different sized subunits, and most of the staining intensity is present in one to three subunits.
Journal ArticleDOI
Carcinoembryonic Antigen in Patients With Different Cancers
Gustavo Reynoso,T.M. Chu,Douglas Holyoke,Elias Cohen,Takuma Nemoto,J-J Wang,J. Chuang,Patrick D. Guinan,Gerald P. Murphy +8 more
TL;DR: The plasma CEA levels measured in 346 patients using a new procedure which detects an ion-sensitive antigenic site in the carcinoembryonic molecule appear to be useful in the follow-up of patients with cancer and may eventually be of diagnostic value in the asymptomatic patient.
Journal Article
Induction of adenocarcinomas of the colon in mice by weekly injections of 1,2-dimethylhydrazine.
TL;DR: Assays of hypoxanthine phosphoribosyltransferase in the villus fraction of the small bowel of the 1,2-dimethylhydrazine hydrochloride-treated tumor-carrier mice indicated lower activity, compared to that of controls.
References
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Journal ArticleDOI
Specific carcinoembryonic antigens of the human digestive system
Phil Gold,Samuel O. Freedman +1 more
TL;DR: It was concluded that the carcinoembryonic antigens represent cellular constituents which are repressed during the course of differentiation of the normal digestive system epithelium and reappear in the corresponding malignant cells by a process of derepressive-dedifferentiation.
Journal ArticleDOI
Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia.
TL;DR: A disease with the characteristics of a leukemia has been found to be serially transmissible in adult Swiss mice by means of cell-free filtrates and intraperitoneal, subcutaneous, intracerebral, and intramuscular injections are all effective.
Journal ArticleDOI
The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system
TL;DR: The test detects a concentration of 2.5 ng of carcinoembryonic antigen per ml of serum and has provided the first demonstration of a circulating tumor-specific antigen in the sera of cancer patients.
Journal ArticleDOI
A transplantable mast-cell neoplasm in the mouse.
Thelma B. Dunn,Michael Potter +1 more
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Specific carcinoembryonic antigens of the human digestive system
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