Open AccessJournal Article
Reversal of multidrug resistance in human K562/ADM cell line by dauricine
TLDR
Dauricine can reverse MDR of K562/ADM to some extent and enhance accumulation of adriamycin and daunorubicin, but cause no change in the expression of P-170.Abstract:
Object: To find effective herb medicine having the potency of reversing multidrug resistance (MDR) Method:Dauricine, one kind of herd medicine,has been selected to study its reversal effect to K562/ADM cell line comparing with verapamil as positive control Results:Dauricine can reduce the value of IC50 of adrimycin and incristine against MDR cell line K562/ADM at non-cytotoxic concentration and enhance accumulation of adriamycin and daunorubicin, but cause no change in the expression of P-170Conclusion:Dauricine can reverse MDR of K562/ADM to some extentread more
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Overcome Cancer Cell Drug Resistance Using Natural Products
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