Q2. What is the main reason for the development of cataract?
refractory disease mandates the use of more potent treatment options for extensive periods of time, and cataract formation may be the result of either the long standing activeinflammation, or as a consequence of corticosteroids.
Q3. What were the common etiologies related to cataract?
The most common etiologies related to cataract were idiopathic (48.6%), JIA (12.9%), antinuclear antibody (ANA) positive vasculitis with no evidence of joint involvement (8.6%), infections (such as acute retinal necrosis, tuberculosis, toxoplasmosis and human immunodeficiency virus infections- 7.8%), idiopathic posterior uveitis (multi focal choroiditis and acute multifocal placoid pigment epitheliopathy- 5.7%), HLA-B27 positive (5%) and Sarcoidosis (4.3%).
Q4. What is the prevalence of cataract in children with JIA?
The prolonged exposure to local inflammatory mediators is known to be related to the development of anterior chamber complications,23 among which cataract formation has the greatest visual impact.
Q5. What is the reason for the development of cataract in uveitis?
One of the reasons for the development of cataract in uveitis may be a consequence of ongoing inflammation and the anatomical location of this inflammation is an important factor.
Q6. What is the common cause of uveitis in children?
Risk of cataract development among children with juvenile idiopathic arthritis-related uveitis treated with topical corticosteroids.
Q7. What was the significant risk factor for cataract development?
Among types of uveitis PanU was found to be a statistically significant risk factor for cataract development (p=0.02), while CAU was related to an increased risk of cataract development, but did not reach statistical significance (p=0.07).
Q8. What is the common complication of uveitis?
Complications of uveitis are considered more prevalent in children than in adults due to delayed diagnosis as well as difficulty in clinical examination and treatment, with the most common complication being cataract.
Q9. What is the prevalence of cataract in the JIA cohort?
Amongst their cohort, cataract developed most commonly in eyes with PanU, CAU and IU respectively, whereas it was far less common in those with PostU, despite extensive use of systemic corticosteroids and local corticosteroids injections,5 suggesting inflammation is a far more significant risk factor.
Q10. What is the main purpose of this study?
To conclude, in this study the authors found that formation of cataract is common among pediatric eyes treated for uveitis and may develop over several years.
Q11. What was the mean follow up time for cataract in the entire cohort?
The mean follow up time was 51.6±3.4 months (range 6-261 months)and the prevalence of cataract in the entire cohort was 44.2% of eyes and occurred in 12.9% of eyes with acute anterior uveitis (AAU), 48.3% of those with chronic anterior uveitis (CAU), 48.0% with intermediate uveitis (IU), 16.7% with posterior uveitis (PostU) and 77.1% with panuveitis (PanU).
Q12. What was the purpose of the study?
The authors investigated clinical and ophthalmological characteristics, as well as treatment strategies in relation to the time interval between the first presentation with uveitis and cataract development.