Open AccessJournal Article
Ritodrine hydrochloride: a betamimetic agent for use in preterm labor. II. Evidence of efficacy.
Irwin R. Merkatz,Irwin R. Merkatz,Irwin R. Merkatz,John B. Peter,John B. Peter,John B. Peter,Tom P. Barden,Tom P. Barden,Tom P. Barden +8 more
TLDR
Results from a multicenter series of randomized prospective doubleblind controlled studies have contributed to ritodrine hydrochloride becoming the first drug approved for the treatment of preterm labor in the United States.About:
This article is published in Obstetrics & Gynecology.The article was published on 1980-07-01 and is currently open access. It has received 140 citations till now. The article focuses on the topics: Ritodrine & Ritodrine Hydrochloride.read more
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Journal ArticleDOI
The management of preterm labor
TL;DR: The most important components of management are aimed at preventing neonatal complications through the use of corticosteroids and antibiotics to prevent group B streptococcal neonatal sepsis, and avoiding traumatic deliveries as discussed by the authors.
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Tocolytics for preterm labor: a systematic review.
TL;DR: Although tocolytics prolong pregnancy, they have not been shown to improve perinatal or neonatal outcomes and have adverse effects on women in preterm labor.
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Tocolytic therapy for preterm delivery: systematic review and network meta-analysis
TL;DR: In this paper, the authors performed a systematic review and network meta-analysis to determine the most effective tocolytic agent at delaying delivery, and found that prostaglandin inhibitors and calcium channel blockers had the highest probability of delaying delivery and improving neonatal and maternal outcomes.
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Beta-mimetics in preterm labour: an overview of the randomized controlled trials.
TL;DR: An unequivocal effect of beta‐mimetic tocolytic administration in delaying delivery is demonstrated, reflected in a reduction in the frequency of preterm birth and low birthweight, but no beneficial effect of this treatment on perinatal mortality or severe neonatal respiratory disorders could be detected.
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An oxytocin receptor antagonist (atosiban) in the treatment of preterm labor: A randomized, double-blind, placebo-controlled trial with tocolytic rescue☆☆☆
Roberto Romero,Bahaeddine M Sibai,Luis Sanchez-Ramos,Guillermo Valenzuela,Jean Claude Veille,Bannie L. Tabor,Kenneth G. Perry,Michael W. Varner,T. Murphy Goodwin,Rosanne Lane,Judith A. Smith,Gary A. Shangold,George W. Creasy +12 more
TL;DR: The treatment of patients in preterm labor with atosiban resulted in prolongation of pregnancy for up to 7 days for those at a gestational age > or =28 weeks, and this occurred with a low rate of maternal-fetal adverse effects.