Journal ArticleDOI
Role and regulation of glucose metabolism in proliferating cells.
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TLDR
The history of the interest in glucose metabolism in malignantly transformed cells dates back to the pioneering studies of Warburg, which led to the statement, in 1956, that the era in which the fermentation of cancer cells could be debated is over and no-one today can doubt that it is necessary to know how their large fermentation originates.Abstract:
The history of the interest in glucose metabolism in malignantly transformed cells dates back to the pioneering studies of Warburg. These studies led to the statement, in 1956: “The era in which the fermentation of cancer cells, or its importance, could be debated is over and no-one today can doubt that we understand the origin of cancer cells if we know how their large fermentation originates, or to express it more fully, if we know how the damaged respiration and the excessive fermentation of cancer cells originates.” Even at this time, doubts were expressed about the respiratory deficiency of tumor cells.read more
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Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
TL;DR: In this paper, the authors provide a detailed accounting of the biosynthetic requirements to construct a new cell and illustrate the importance of glycolysis in providing carbons to generate biomass.
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The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells
TL;DR: It is suggested that, in rapidly dividing ceils, high rates of glycolysis and glutaminolysis are required not for energy or precursor provision per se but for high sensitivity of the pathways involved in the use of precursors for macromolecular synthesis to specific regulators to permithigh rates of proliferation when required for example, in lymphocytes in response to a massive infection.
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Changes in requirements and utilization of nutrients during mammalian preimplantation embryo development and their significance in embryo culture
TL;DR: Quantification of embryo energy metabolism may serve as a valuable marker of embryo development and viability in the face of in vitro-induced cellular stress.
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Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways.
Norma Masson,Peter J. Ratcliffe +1 more
TL;DR: Current understanding of the role of hypoxia inducible factor (HIF) in these networks is summarized and the implications of switching massive pathways that are physiologically 'hard-wired’ to oncogenic mechanisms driving cancer are discussed.
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Enzymes of serine metabolism in normal, developing and neoplastic rat tissues.
TL;DR: The hypothesis was proposed that the mitochondrial isoenzyme of serine hydroxymethyltransferase is associated together with serine aminotransferase in a pathway for gluconeogenesis from protein-derived amino acids such as glycine and hydroxyproline.
References
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Journal Article
Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes.
TL;DR: The studies suggest that the mitogenic action of PHA does not involve mitosis per se but rather the stage preceding mitosis—the alteration of circulating monocytes and large lymphocytes to a state wherein they are capable of division.
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Transport of nucleosides, nucleic acid bases, choline and glucose by animal cells in culture.
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A Unifying Hypothesis Concerning the Nature of Malignant Growth
TL;DR: It is suggested that the crucial change in a malignant cell is an alteration in the cell surface membrane that results in increased internal concentrations of nutrients that regulate cell growth.
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Induction of increased calcium uptake in mouse T lymphocytes by concanavalin A and its modulation by cyclic nucleotides.
TL;DR: The binding of concanavalin A to T but not B mouse spleen lymphocytes increases Ca2+ uptake in these cells which is measurable by 45 s and complete by 1 min.