Open AccessJournal Article
Role of adenine and guanine nucleotides in the activity and response of adenylate cyclase systems to hormones: evidence for multisite transition states.
Martin Rodbell,Michael C. Lin,Yoram Salomon,Constantine Londos,Harwood Jp,Martin Br,M Rendell,Berman M +7 more
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This article is published in Advances in cyclic nucleotide research.The article was published on 1975-01-01 and is currently open access. It has received 127 citations till now. The article focuses on the topics: Cyclase & Guanine.read more
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Journal ArticleDOI
Subclasses of external adenosine receptors
TL;DR: The potency of adenosine is intermediate between the potencies of these two analogs and is maintained in physiological responses in intact cells, such as steroidogenesis and inhibition of lipolysis.
Journal ArticleDOI
Two distinct central serotonin receptors with different physiological functions
TL;DR: The limited correlation of drug effects with regulation by guanine nucleotides suggests that serotonin 1 sites might be linked to adenylate cyclase and drug specificities of serotonin-elicited synaptic inhibition and excitation may reflect serotonin 1 and serotonin 2 receptor interactions.
Journal Article
Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands.
TL;DR: Although most of the chosen compounds did not discriminate between CB1 and CB2, several ligands were identified that showed selectivity and can now serve as a basis for the design of compounds with even greater selectivity.
Journal ArticleDOI
cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide
Juan C. Sáez,David C. Spray,Angus C. Nairn,Elliot L. Hertzberg,Paul Greengard,Michael V. L. Bennett +5 more
TL;DR: The rapid increases in gap junctional conductance caused by agents that elevate cAMP and phosphorylation of the gap junction protein by cAMP-dependent protein kinase suggest that camp-dependent phosphorylated of thegap junction channel modulates the conductance of liver gap junctions.
Book ChapterDOI
The role of cyclic nucleotides in central synaptic function.
TL;DR: Sutherland et al. as mentioned in this paper showed that cyclic AMP functioned as an intracellular second messenger, synthesized in response to certain hormones and which, by activating the appropriate sequence of enzymes, produced the specific biologic response of the target cell to the hormone.