Journal ArticleDOI
The role of hormone receptors and GTP-regulatory proteins in membrane transduction
TLDR
Cell membrane receptors for hormones and neurotransmitters form oligomeric complexes with GTP-regulatory proteins and inhibit the latter from reacting with G TP, and this theory may apply generally to membrane signal transduction involving surface receptors.Abstract:
Cell membrane receptors for hormones and neurotransmitters form oligomeric complexes with GTP-regulatory proteins and inhibit the latter from reacting with GTP. Hormones and neurotransmitters act by releasing the inhibitory constraints imposed by the receptors, thus allowing the GTP-regulatory proteins to interact with and control the activity of enzymes such as adenylate cyclase. This theory may apply generally to membrane signal transduction involving surface receptors.read more
Citations
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Journal ArticleDOI
Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.
TL;DR: F Forskolin would appear to activate adenylate cyclase through a unique mechanism involving both direct activation of the enzyme and facilitation or potentiation of the modulation of enzyme activity by receptors or the guanyl nucleotide-binding subunit, or both.
Journal ArticleDOI
Calcium channel modulation by neurotransmitters, enzymes and drugs
TL;DR: Calcium channels in excitable membranes are of great importance for many cellular functions and modulation by neurotransmitters and drugs regulates calcium influx into the cell and thereby alters the functional state of the cell.
Journal ArticleDOI
G Protein Pathways
TL;DR: The heterotrimeric guanine nucleotide–binding proteins (G proteins) are signal transducers that communicate signals from many hormones, neurotransmitters, chemokines, and autocrine and paracrine factors, which regulate systemic functions such as embryonic development, gonadal development, learning and memory, and organismal homeostasis.
Journal ArticleDOI
Receptor-effector coupling by G proteins
TL;DR: To facilitate the reading of this review, the various subtopics of this rapidly expanding field are presented, each of which is organized as a self-contained sub-chapter that can be read independently of the others.
Journal ArticleDOI
Subclasses of external adenosine receptors
TL;DR: The potency of adenosine is intermediate between the potencies of these two analogs and is maintained in physiological responses in intact cells, such as steroidogenesis and inhibition of lipolysis.
References
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Journal ArticleDOI
Multiple receptors for dopamine.
John W. Kebabian,Donald B. Calne +1 more
TL;DR: Pharmacological and biochemical criteria can be used to separate those dopamine receptors which are linked to the enzyme adenylyl cyclase and those which are not.
Journal ArticleDOI
Coated pits, coated vesicles, and receptor-mediated endocytosis
TL;DR: It is now recognised that receptor-mediated endocytosis has a fundamental role in the growth, nutrition and differentiation of animal cells.
Journal ArticleDOI
Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the “dopamine receptor”
TL;DR: The results suggest that dopamine-sensitive adenylate cyclase may be the receptor for dopamine in mammalian brain and should facilitate the search for new therapeutic agents useful in the treatment of extrapyramidal diseases.
Journal ArticleDOI
Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system
Dan Cassel,Thomas Pfeuffer +1 more
TL;DR: The results indicate that cholera toxin affects the adenylate cyclase system by catalyzing an ADP-ribosylation of the 42,000-M(r) component bearing the guanyl nucleotide regulatory site.