Role of Montelukast as Monotherapy in Improving Quality of Life of an Asthmatic Patient in Pakistan
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TLDR
Montelukast has an effective role in asthma control as well as in improving the quality of life in the Pakistani population by comparing it with placebo.Abstract:
Introduction Uncontrolled and inadequately managed asthma substantially reduces Quality of Life (QOL) and can lead to premature death. The aim of this study is to understand the role of montelukast in improving quality of life in asthmatic patients by comparing it with placebo. Methods This prospective, single-arm, interventional study was conducted from September 2019 to February 2020 in the pulmonology outpatient department of a tertiary care hospital in Pakistan. All patients were prescribed montelukast (10 mg once daily). Results At day 28, participants had a higher score on the Asthma Quality of Life Questionnaire-Standard (AQLQ-S) overall and in all sub-domains compared to day 0. The improvement was significant overall and for the sub-domains of symptoms, activity limitations, and environmental stimuli. Conclusion Montelukast has an effective role in asthma control as well as in improving the quality of life in the Pakistani population.read more
Citations
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Proceedings ArticleDOI
The CysLT1receptor antagonist montelukast blocks bronchoconstriction induced by inhaled leukotriene E4in subjects with asthma
TL;DR: Montelukast profoundly inhibited the bronchoconstriction induced by inhaled LTE 4 in subjects with mild asthma, suggesting that the effects of LTE 4 on human airways are mediated solely by the CysLT 1 receptor.
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TL;DR: Montelukast 10mg is a safe and effective treatment for patients with both asthma and allergic rhinitis and overall QoL was "very good" or "good" in 85.2% of patients and a "strong" or 'marked' improvement in each of the four domains of sleep, work, everyday life and physical activity.
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