Journal ArticleDOI
Role of neuropeptides in anxiety, stress, and depression: from animals to humans.
TLDR
Based on data obtained in animal studies, neuropeptides and their receptors might be targeted by new candidate neuropharmacons with the hope that they will become important and effective tools in the management of stress related mood disorders.About:
This article is published in Neuropeptides.The article was published on 2013-12-01. It has received 272 citations till now. The article focuses on the topics: Urocortin & Mood disorders.read more
Citations
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The Effects of Psychological Stress on Depression
TL;DR: This review will review classical models along with new methods that will enrich knowledge of this disorder to elucidate the physiopathology underlying depression and to treat depressive symptoms.
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Postpartum depression: Etiology, treatment and consequences for maternal care
TL;DR: The literature on postnatal depression in the mother and its effect on mother-infant interactions is reviewed and interventions during gestation and postpartum that may improve maternal symptoms and behavior and thus alter developmental outcome of the offspring are discussed.
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Sex differences in depression: Insights from clinical and preclinical studies.
TL;DR: Evidence is provided to support the notion that differences in depression between men and women span multiple facets of the disease, including epidemiology, symptomology, treatment, and pathophysiology, and a more systematic consideration of biological sex as a variable in depression research will be critical in the discovery and development of pharmacotherapies that are efficacious for both men andWomen.
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The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress
Moriel Zelikowsky,May Hui,Tomomi Karigo,Andrea Choe,Bin Yang,Mario Blanco,Keith Beadle,Viviana Gradinaru,Benjamin E. Deverman,David J. Anderson +9 more
TL;DR: Tac2 coordinates a pleiotropic brain state caused by SIS via a distributed mode of action and is suggested for potential new therapeutic applications for Nk3R antagonists.
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Stress Modulation of Opposing Circuits in the Bed Nucleus of the Stria Terminalis.
TL;DR: This review will examine how stress interacts with the neuromodulators, corticotropin-releasing factor, norepinephrine, dopamine, and serotonin to affect the circuitry of the BNST as well as how synaptic plasticity in the BnST is modulated by stress, resulting in long-lasting changes in the circuit and behavioral state.
References
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Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin
TL;DR: A peptide with high potency and intrinsic activity for stimulating the secretion of corticotropin-like and β-endorphinlike immunoactivities by cultured anterior pituitary cells has been purified in this paper.
Journal ArticleDOI
A Syndrome produced by Diverse Nocuous Agents
TL;DR: If the organism is severely damaged by acute non-specific nocuous agents such as exposure to cold, surgical injury, production of spinal shock, excessive muscular exercise, or intoxications with sublethal doses of diverse drugs, a typical syndrome appears, the symptoms of which are independent of the nature of the damaging agent or the pharmacological type of the drug employed.
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Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain
TL;DR: As an adjunct to pharmaceutical therapy, social and behavioral interventions such as regular physical activity and social support reduce the chronic stress burden and benefit brain and body health and resilience.
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The Oxytocin Receptor System: Structure, Function, and Regulation
Gerald Gimpl,Falk Fahrenholz +1 more
TL;DR: The regulation by gonadal and adrenal steroids is one of the most remarkable features of the OT system and is, unfortunately, the least understood.
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Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress.
TL;DR: CRH antagonists may be useful in human pathologic states, such as melancholic depression and chronic anxiety, associated with chronic hyperactivity of the stress system, along with predictable behavioral, neuroendocrine, metabolic and immune changes, based on the interrelations outlined above.