Journal ArticleDOI
Schistosoma mansoni: chemotherapy of infections of different ages.
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TLDR
Worms that had been subjected to amoscanate or hycanthone in the third week after infection showed evidence of this as adults in having a reduced fecundity, and factors such as worm or host physiology, or host immune status may have had roles in the outcome of chemotherapy at different stages of maturation of S. mansoni.About:
This article is published in Experimental Parasitology.The article was published on 1986-06-01. It has received 333 citations till now. The article focuses on the topics: Oxamniquine & Hycanthone.read more
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Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis.
TL;DR: Use of PZQ will increase in the foreseeable future, whether given alone or coadministered with other anthelminthics in integrated control programmes, as well as inhibitors of a schistosome-specific bifunctional enzyme, thioredoxin-glutathione reductase.
Journal ArticleDOI
Time to set the agenda for schistosomiasis elimination.
David Rollinson,Stefanie Knopp,Stefanie Knopp,Sarah Levitz,J. Russell Stothard,Louis-Albert Tchuem Tchuenté,Amadou Garba,Amadou Garba,Khalfan A. Mohammed,Nadine Schur,Nadine Schur,Bobbie Person,Daniel G. Colley,Jürg Utzinger,Jürg Utzinger +14 more
TL;DR: An agenda for the elimination of schistosomiasis would aim to identify the gaps in knowledge, and define the tools, strategies and guidelines that will help national control programmes move towards elimination, including an internationally accepted mechanism that allows verification/confirmation of elimination.
Journal ArticleDOI
Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers.
Ismail Mm,Sanaa S. Botros,Aiesha Metwally,Samia William,Adel Farghally,Liang-Fang Tao,Tim A. Day,James L. Bennett +7 more
TL;DR: It is concluded that the in vitro action of the drug is related to its in vivo action and this relationship will assist in the ability to detect or survey for the PZQ resistant phenotype in human populations.
Journal ArticleDOI
Schistosomiasis and soil-transmitted helminthiasis: common drugs for treatment and control
Jürg Utzinger,Jennifer Keiser +1 more
TL;DR: The geographical distribution, life cycle and global burden of schistosomiasis and STH is summarized, and the current arsenal of drugs available for morbidity control, including discovery, chemistry, pharmacological properties and aspects of therapeutic efficacy and adverse events in clinical human use are discussed.
Journal ArticleDOI
Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target
Angela N Kuntz,Elisabeth Davioud-Charvet,Elisabeth Davioud-Charvet,Ahmed A. Sayed,Lindsay L. Califf,Jean Dessolin,Jean Dessolin,Elias S.J. Arnér,David L. Williams +8 more
TL;DR: Investigating the potential of a unique, selenium-containing parasite enzyme thioredoxin glutathione reductase (TGR) as a drug target indicates that parasite TGR meets all the major criteria to be a key target for antischistosomal chemotherapy.
References
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Journal ArticleDOI
The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms.
S. R. Smithers,R. J. Terry +1 more
TL;DR: Smithers and Terry as discussed by the authors described techniques which are rapid and do not require great skill in their performance, and in their hands they have given very consistent results, in this respect they believe that these techniques have advantages over others which are currently practised.
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Praziquantel, a new board-spectrum antischistosomal agent.
Rudolf Gönnert,Peter Dr Andrews +1 more
TL;DR: Praziquantel is equally effective against both sexes of S. mansoni and less effective against unpaired and therefore juvenile female worms, but fully effective against single male worms.
Journal Article
Conditions affecting the accuracy of potassium hydroxide digestion techniques for counting Schistosoma mansoni eggs in tissues.
Journal Article
In vivo and in vitro experiments on the effects of praziquantel on Schistosoma mansoni. A light and electron microscopic study.
TL;DR: The effects of 2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one on Schistosoma mansoni was studied in vivo and in vitro by means of electron microscopy.
Journal ArticleDOI
Schistosoma mansoni: Reduced efficacy of chemotherapy in infected T-cell-deprived mice
TL;DR: The effect of host immunosuppression on the efficacy of schistosomicidal chemotherapy has been tested in T-cell-deprived CBA mice infected with Schistosoma mansoni, and the possibility that hycanthone, oxamniquine, praziquantel, and previously studied antimony act synergistically with immune effector mechanisms in killing adultschistosomes is discussed.