Journal ArticleDOI
Severe central-nervous-system toxicity associated with cyclosporin
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This article is published in The Lancet.The article was published on 1985-01-26. It has received 115 citations till now. The article focuses on the topics: Toxicity & Central nervous system.read more
Citations
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Journal ArticleDOI
Neurotoxicity of calcineurin inhibitors: impact and clinical management.
TL;DR: CsA- Sparing and tacrolimus-sparing drug regimens that use the immunosuppressant mycophenolate mofetil, which has no neurotoxic effects, may reduce the incidence and severity of neurotoxic adverse events while maintaining an adequate level of immunoisuppression.
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Central Nervous System Toxicity after Liver Transplantation
TL;DR: It is concluded that cyclosporine therapy for immunosuppression in liver transplantation may cause a syndrome of encephalopathy, seizures, and white-matter changes and that this is most likely to occur in patients with low total serum cholesterol levels after transplantation.
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Cyclosporine neurotoxicity: a review.
TL;DR: Dose reduction or withdrawal of CsA usually results in resolution of clinical symptoms and of neuroimaging abnormalities, and Neurotoxicity is more frequent with high C'sA blood levels, but levels may be within the therapeutic range.
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Mitochondrial permeability transition in CNS trauma: cause or effect of neuronal cell death?
TL;DR: A comprehensive and critical look at the evidence supporting the role for mPT in central nervous system (CNS) trauma and highlights the differential responses of CNS mitochondria to mPT induction and the implications this has for therapeutically targeting the m PT in TBI and SCI.
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Cyclosporin A significantly ameliorates cortical damage following experimental traumatic brain injury in rodents.
TL;DR: Amelioration of cortical damage with CsA indicates that pharmacological therapies can be devised that will significantly alter neurological outcome after injury and suggest that the mechanisms responsible for tissue necrosis following TBI are amenable to manipulation.
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Journal ArticleDOI
Association between cyclosporin neurotoxicity and hypomagnesaemia
TL;DR: The serum magnesium levels of all 12 allogeneic bone-marrow transplant recipients who experienced the neurotoxic effects of cyclosporin (CyA) were more than two standard deviations below the normal range and the neurological events seemed to segregate into three separate syndromes.
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Hypertension and convulsions in children receiving cyclosporin A.
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Cyclosporin A, methylprednisolone, and convulsions.
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Cyclosporine-Associated Central Nervous System Toxicity After Allogeneic Bone Marrow Transplantation
TL;DR: Five recipients of HLA-identical sibling marrow allografts who were given cyclosporin to minimize graft-versus-host disease posttransplant had a serious neurological illness thought to be due to CSP, and all five recovered when the CSP dose was reduced or the drug was stopped.
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Diagnosis of Progressive Multifocal Leukoencephalopathy by Computed Tomography
TL;DR: The distinctive CT appearance in three documented cases includes low-density lesions of central and convolutional white matter with scalloped lateral borders that demonstrate no mass effect or contrast material enhancement.