Journal ArticleDOI
Sex differences in dendritic atrophy of ca3 pyramidal neurons in response to chronic restraint stress
Liisa A.M. Galea,Bruce S. McEwen,Patima Tanapat,Terrence Deak,Robert L. Spencer,Firdaus S. Dhabhar +5 more
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TLDR
It appears unlikely that sex differences in the corticosteroid-binding globulin and corticosterone response can account for these morphological differences found in males and females.About:
This article is published in Neuroscience.The article was published on 1997-09-26. It has received 529 citations till now. The article focuses on the topics: Chronic stress & Corticosterone.read more
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Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain
TL;DR: As an adjunct to pharmaceutical therapy, social and behavioral interventions such as regular physical activity and social support reduce the chronic stress burden and benefit brain and body health and resilience.
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The neurobiology of stress : from serendipity to clinical relevance
TL;DR: In this article, the effects of stress on the immune system and brain are discussed and two new terms, allostasis and allostatic load, are introduced to supplement and clarify the meanings of stress and homeostasis.
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Estrogen actions in the central nervous system.
Bruce S. McEwen,Stephen E. Alves +1 more
TL;DR: This work has shown that estrogens, Neuroprotection, and Alzheimer’s Disease are intertwined and that the effects of estrogens on learning and memory are determined by the mechanism of action of the hormone.
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Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex
TL;DR: Findings in animal models have resulted in translation to the human brain and have helped change thinking about the nature of brain malfunction in psychiatric disorders and during aging, as well as the mechanisms of the effects of early-life adversity on the brain and the body.
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Neurobiology of Resilience
TL;DR: A growing literature in rodents is highlighted that is starting to complement the human work by identifying the active behavioral, neural, molecular and hormonal basis of resilience, which can pave the way for an innovative approach to drug development for a range of stress-related syndromes.
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Journal ArticleDOI
Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons.
TL;DR: Repeated daily restraint stress for 21 days caused apical dendrites of CA3 pyramidal neurons to atrophy, while basal CA3 dendrite levels did not change.
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Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: Involvement of glucocorticoid secretion and excitatory amino acid receptors
TL;DR: The results indicate that the reversible atrophy induced by 21 days of daily restraint stress requires corticosterone secretion and that excitatory mechanisms involving N-methyl-D-aspartate receptors play a major role in driving the atrophy.
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Gonadal Steroid Hormone Receptors and Sex Differences in the Hypothalamo-Pituitary-Adrenal Axis
TL;DR: The results of a variety of studies suggest that gonadal steroid hormones, particularly testosterone, modulate HPA activity in an attempt to prevent the deleterious effects of HPA activation on reproductive function.
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Repeated stress causes reversible impairments of spatial memory performance
TL;DR: These effects on behavior parallel the reversible stress-induced atrophy of dendrites of hippocampal CA3 neurons that are also blocked by the drugs.
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Hippocampal damage associated with prolonged and fatal stress in primates
TL;DR: This paper showed that sustained exposure to glucocorticoids (GCs), adrenal hormones secreted during stress, can cause neural degeneration in the rat hippocampus, particularly in the hippocampus, a principal neural target site for GCs.