Journal ArticleDOI
Solubility of 9-fluorenone, thianthrene and xanthene in organic solvents
TLDR
In this article, the Abraham solvation parameter model is used to calculate the numerical values of the solute descriptors for 9-fluorenone, thianthrene and xanthene from experimental solubilities in organic solvents.About:
This article is published in Fluid Phase Equilibria.The article was published on 2005-05-25. It has received 68 citations till now. The article focuses on the topics: Solvation & Solubility.read more
Citations
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Journal ArticleDOI
Prediction of solubility of drugs and other compounds in organic solvents
Michael H. Abraham,Robert E. Smith,Robert E. Smith,Ron Luchtefeld,Aaron J. Boorem,Rensheng Luo,William E. Acree +6 more
TL;DR: A procedure for the prediction of solubilities of drugs and other compounds in a wide range of solvents, based on the Abraham solvation equations, which is especially useful for very hydrophobic compounds such as cholesteryl acetate and cholesterol.
Journal ArticleDOI
Solubility of Chlordiazepoxide, Diazepam, and Lorazepam in Ethanol + Water Mixtures at 303.2 K
Abolghasem Jouyban,Javad Shokri,Mohammad Barzegar-Jalali,Davoud Hassanzadeh,William E. Acree,Taravat Ghafourian,Ali Nokhodchi +6 more
TL;DR: In this article, the experimental solubilities of three benzodiazepines (chlordiazepoxide, diazepam, and lorazepam) in ethanol + water mixtures at 303.2 K were reported.
Book ChapterDOI
Experimental and Computational Methods Pertaining to Drug Solubility
TL;DR: There are various methods for solubility determination of drugs which are discussed in this chapter as mentioned in this paper and the experimental determination is tedious and time-consuming process and sometimes there is restrictions in the availability of enough amount of a drug candidate to be used in the solubability measurements, especially in the early stages of drug discovery investigations in which only small amount of drug is synthesized/extracted and large number of preliminary biological tests should be carried out.
Journal ArticleDOI
Solubility of naproxen in 2-propanol + water mixtures at various temperatures
TL;DR: In this paper, the experimental solubility of naproxen in 2-propanol + water mixtures at different temperatures (298.2, 303.2 and 313.2 K) was reported.
Journal ArticleDOI
Microbial production of short and medium chain esters: Enzymes, pathways, and applications.
Aleksander J. Kruis,Anna C. Bohnenkamp,Constantinos Patinios,Youri M. van Nuland,Mark Levisson,Astrid E. Mars,Corjan van den Berg,Servé W. M. Kengen,Ruud A. Weusthuis +8 more
TL;DR: This review provides a broad overview of natural ester production by microorganisms and focusses on the physical properties of short and medium chain esters, which may simplify downstream processing, while limiting the effects of product toxicity.
References
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Journal ArticleDOI
Determination of sets of solute descriptors from chromatographic measurements
TL;DR: It is concluded that for processes that entail transfer of a solute from one phase to another, only a small number of solute descriptors is needed to provide a reasonably accurate analysis of the process.
Journal ArticleDOI
Octanol‐Water Partition Coefficients of Simple Organic Compounds
TL;DR: In this paper, the Octanol Water Particle Coefficients (LWC) for 611 simple organic compounds representing all principal classes have been retrieved from the literature and available experimental details of measurement are documented from original articles.
Journal ArticleDOI
The use of characteristic volumes to measure cavity terms in reversed phase liquid chromatography
Michael H. Abraham,J. C. McGowan +1 more
TL;DR: In this paper, it was shown that the use of the McGowans characteristic volume, Vx, is equivalent to using Leahy's computer-calculated intrinsic volumes, V1, for the cavity term mV/100, for 209 gaseous, liquid, and solid solutes.
Journal ArticleDOI
Retention indices for programmed-temperature capillary-column gas chromatography of polycyclic aromatic hydrocarbons
Journal ArticleDOI
Is rain or snow a more efficient scavenger of organic chemicals
Ying Duan Lei,Frank Wania +1 more
TL;DR: In this article, the authors compared the capacity of rain and snow to scavenge gaseous and particle-bound organic contaminants from the atmosphere at different temperatures and found that at 0°C rain is more effective in scavenging the vapors of small organic molecules than snow, because the snow surface to sorb such chemicals is smaller than that of liquid water droplets.