Journal ArticleDOI
Staphylococcus aureus; drug-fastness studies with penicillin and sulfactin.
TLDR
A strain of staphylococci in becoming resistant to penicillin did not show an increase in its resistance to sulfactin and the increase in resistance developed by a strain of E. coli to streptomycin was intermediate.Abstract:
SummaryA strain of staphylococci in becoming resistant to penicillin did not show an increase in its resistance to sulfactin. A similar strain of staphylococci in becoming resistant to sulfactin di...read more
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Resistance to antibiotics: are we in the post-antibiotic era?
TL;DR: Antibiotic resistance, initially a problem of the hospital setting associated with an increased number of hospital-acquired infections usually in critically ill and immunosuppressed patients, has now extended into the community causing severe infections difficult to diagnose and treat.
Journal ArticleDOI
A Review of the Research Literature on Evidence-Based Healthcare Design
Roger S. Ulrich,Craig Zimring,Xuemei Zhu,Jennifer R. DuBose,Hyun-Bo Seo,Young-Seon Choi,Xiaobo Quan,Anjali Joseph +7 more
TL;DR: This review found a growing body of rigorous studies to guide healthcare design, especially with respect to reducing the frequency of hospital-acquired infections and the state of knowledge of evidence-based healthcare design has grown rapidly in recent years.
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Efflux-Mediated Drug Resistance in Bacteria
Xian-Zhi Li,Hiroshi Nikaido +1 more
TL;DR: Fluoroquinolones and β-lactams of the latest generations are likely to select for overproduction mutants of these pumps and make the bacteria resistant in one step to practically all classes of antibacterial agents.
Journal ArticleDOI
Relationship of MIC and Bactericidal Activity to Efficacy of Vancomycin for Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia
George Sakoulas,Pamela A. Moise-Broder,Jerome J. Schentag,Alan Forrest,Robert C. Moellering,George M. Eliopoulos +5 more
TL;DR: It is concluded that a significant risk for vancomycin treatment failure in MRSA bacteremia begins to emerge with increasing vancomYcin MICs well within the susceptible range.
Journal ArticleDOI
Food poisoning and Staphylococcus aureus enterotoxins.
TL;DR: Genes encoding novel SEs as well as SEls with untested emetic activity are widely represented in S. aureus, and their role in pathogenesis may be underestimated.