Journal ArticleDOI
Steady flow in a model of the human carotid bifurcation. Part I--flow visualization.
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Comparison with pathologic data on localization of atherosclerotic lesions indicates that zones susceptible to disease experience low or oscillatory shear stress while regions subject to higher shear are free of deposits.About:
This article is published in Journal of Biomechanics.The article was published on 1982-01-01. It has received 326 citations till now. The article focuses on the topics: Flow visualization & Shear stress.read more
Citations
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Journal ArticleDOI
Hemodynamic shear stress and its role in atherosclerosis.
TL;DR: The functional regulation of the endothelium by local hemodynamic shear stress provides a model for understanding the focal propensity of atherosclerosis in the setting of systemic factors and may help guide future therapeutic strategies.
Journal ArticleDOI
Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress.
TL;DR: These studies confirm earlier findings under steady flow conditions that plaques tend to form in areas of low, rather than high, shear stress, but indicate in addition that marked oscillations in the direction of wall shear may enhance atherogenesis.
Journal ArticleDOI
Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives
Jeng Jiann Chiu,Shu Chien +1 more
TL;DR: Current knowledge on the role of disturbed flow in EC physiology and pathophysiology, as well as its clinical implications are summarized to contribute to the understanding of the etiology of lesion development in vascular niches with disturbed flow and help to generate new approaches for therapeutic interventions.
Journal ArticleDOI
Carotid bifurcation atherosclerosis. Quantitative correlation of plaque localization with flow velocity profiles and wall shear stress.
Christopher K. Zarins,Don P. Giddens,B. K. Bharadvaj,V S Sottiurai,R.F. Mabon,Seymour Glagov +5 more
TL;DR: It is concluded that in the human carotid bifurcation, regions of moderate to high shear stress, where flow remains unidirectional and axially aligned, are relatively spared of intimal thickening.
Journal ArticleDOI
Flow patterns and spatial distribution of atherosclerotic lesions in human coronary arteries.
T Asakura,Takeshi Karino +1 more
TL;DR: The results indicate that the major hemodynamic factors directly related to the localization of atherosclerotic plaques and wall thickenings in the human arterial system are the low fluid velocity and the resultant low shear stress that acts on the vessel wall.
References
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Journal ArticleDOI
XVI. Note on the motion of fluid in a curved pipe
TL;DR: In this paper, the motion of fluid in a curved pipe is described as follows: "note on the motion in a curve pipe" and "the motion in the fluid in the curved pipe".
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Atheroma and arterial wall shear. Observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis.
TL;DR: It appears that wall shear rate may be a major controlling factor in the development of atheromatous lesions in man and in animals and a net flux of cholesterol from blood to wall cannot account for the observed normally occurring (quasi-steady state) and experimentally induced atheroma.
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Acute Vascular Endothelial Changes Associated with Increased Blood Velocity Gradients
TL;DR: The purpose of this study is to quantify the acute changes in endothelial histology that are associated with an induced increase in blood velocity and to establish the “normal” endothelial cell population density as a function of stress exposure.
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Flow patterns in models of the human bronchial airways.
R.C. Schroter,M.F. Sudlow +1 more
TL;DR: Flow profiles were studied in two successive generations of large scale symmetrical models of typical junctions of the human bronchial tree, suggesting that flow patterns are complex and parabolic flow cannot be assumed.
Journal ArticleDOI
Steady laminar flow through modelled vascular stenoses.
TL;DR: Numerical solutions for steady flow through axisymmetric, contoured constrictions in a rigid tube are presented, utilizing the full Navier-Stokes equations in cylindrical coordinates, compared with available experimental data.