Journal ArticleDOI
Stereochemistry of biosynthesis of the vinyl groups of protoporphyrin-IX: a short synthesis of porphobilinogen
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Porphobilinogen (1), [2H]-labelled in the propionic residue, is synthesised by a short route and is used to establish that both vinyl groups of protoporphyrin-IX are biosynthesised by overall antiperiplanar elimination of a proton and carbon dioxide.Abstract:
Porphobilinogen (1), [2H]-labelled in the propionic residue, is synthesised by a short route and is used to establish that both vinyl groups of protoporphyrin-IX are biosynthesised by overall antiperiplanar elimination of a proton and carbon dioxide.read more
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Structure and function of enzymes in heme biosynthesis.
TL;DR: This review summarizes the current understanding of the structure–function relationship for all heme biosynthetic enzymes and their potential interactions in the cell.
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Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product.
Harry A. Dailey,Tamara A. Dailey,Svetlana Gerdes,Dieter Jahn,Martina Jahn,Mark R. O'Brian,Martin J. Warren +6 more
TL;DR: Diversity in the regulation of these pathways reflects the diversity of bacterial metabolism and has significantly slowed advances in this field such that no single organism's heme synthesis pathway regulation is currently completely characterized.
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Hemes, chlorophylls, and related compounds: biosynthesis and metabolic regulation.
S. Granick,Samuel I. Beale +1 more
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A new approach to porphobilinogen and its analogs
Christine Y. de Leon,Bruce Ganem +1 more
TL;DR: The van Leusen pyrrole synthesis was used to assemble three potential precursors of porphobilinogen, one of which was converted to the natural product using a new method for the direct alkylation of β-hydroxymethylpyrroles.
Journal ArticleDOI
A General Method for the Preparation of 4- and 6-Azaindoles
TL;DR: Nitropyridines reacted with an excess of vinyl Grignard reagent to produce 4- or 6-azaindoles and improved yields were obtained when a halogen atom was present at the position alpha to the nitrogen atom in the pyridine ring.
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