Journal ArticleDOI
Stereocontrolled total synthesis of (-)-maytansinol
About:
This article is published in Journal of the American Chemical Society.The article was published on 1982-09-01. It has received 74 citations till now. The article focuses on the topics: Total synthesis & Lactam.read more
Citations
More filters
Journal ArticleDOI
Antibody-drug conjugates: an emerging concept in cancer therapy
TL;DR: How the lessons learned from the first-generation ADCs have led to improvements in every aspect of this technology, i.e., the antibody, the cytotoxic compound, and the linker connecting them, leading to the current successes are described.
Journal ArticleDOI
Stereochemical Control in Organic-Synthesis Using Silicon-Containing Compounds
Journal ArticleDOI
Recent developments in the maytansinoid antitumor agents.
TL;DR: New developments in this field during the last two decades include the use of maytansinoids as "warheads" in tumor-specific antibodies, preliminary metabolism studies, investigations of their biosynthesis at the biochemical and genetic level, and ecological issues related to the occurrence of such typical microbial metabolites in higher plants.
Journal ArticleDOI
Synthesis of Methylene- and Alkylidenecyclopropane Derivatives.
Alberto Brandi,Andrea Goti +1 more