Institution
University of Beira Interior
Education•Covilha, Portugal•
About: University of Beira Interior is a education organization based out in Covilha, Portugal. It is known for research contribution in the topics: Population & Context (language use). The organization has 2941 authors who have published 8801 publications receiving 154281 citations. The organization is also known as: Universidade da Beira Interior.
Papers published on a yearly basis
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TL;DR: Reductions in all-cause mortality, major vascular events and revascularisations were found with no excess of adverse events among people without evidence of CVD treated with statins, and evidence available to date showed that primary prevention with statin is likely to be cost-effective and may improve patient quality of life.
Abstract: Cardiovascular disease (CVD), which comprises heart attacks (myocardial infarction), angina and strokes, is ranked as the number one cause of mortality and is a major cause of morbidity world wide. High blood cholesterol is linked to CVD events and is an important risk factor. Reducing high blood cholesterol, is thus an important way to reduce the chances of suffering a CVD event. Statins - cholesterol lowering drugs - (e.g. simvastatin, pravastatin, atorvastatin) are the first-choice treatments. Since the early statin randomised controlled trials were reported in the 1990s, several reviews of the effects of statins have been published highlighting their benefits particularly in people with a past history of CVD. Benefits include a reduction in CVD events. Statins have also been shown to reduce the risk of a first event in otherwise healthy individuals at high risk of CVD (primary prevention) but information on possible hazards has not been reported fully. The aim of this updated systematic review is to assess the effects, both in terms of benefits and harms of statins, for the primary prevention of CVD. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and EMBASE until 2011. We found 18 randomised controlled trials with 19 trial arms (56,934 patients) dating from 1994 to 2008. All were randomised control trials comparing statins with usual care or placebo. The mean age of the participants was 57 years (range 28 - 97 years), 60.3% were men, and of the eight trials that reported on ethnicity, 85.9 % were Caucasian. Duration of treatment was a minimum one year and with follow-up of a minimum of six months. All-cause mortality and fatal and non-fatal CVD events were reduced with the use of statins as was the need for revascularisation (the restoration of an adequate blood supply to the heart) by means of surgery (coronary artery bypass graft ) or by angioplasty (PTCA). Of 1000 people treated with a statin for five years, 18 would avoid a major CVD event which compares well with other treatments used for preventing cardiovascular disease. Taking statins did not increase the risk of serious adverse effects such as cancer. Statins are likely to be cost-effective in primary prevention.
1,456 citations
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CERN1, Goethe University Frankfurt2, University of Beira Interior3, University of Leeds4, University of Helsinki5, Helsinki Institute of Physics6, University of Vienna7, University of Innsbruck8, Paul Scherrer Institute9, Leibniz Association10, University of Milan11, California Institute of Technology12, Lebedev Physical Institute13, University of Eastern Finland14, Earth System Research Laboratory15, Finnish Meteorological Institute16
TL;DR: First results from the CLOUD experiment at CERN are presented, finding that atmospherically relevant ammonia mixing ratios of 100 parts per trillion by volume, or less, increase the nucleation rate of sulphuric acid particles more than 100–1,000-fold and ion-induced binary nucleation of H2SO4–H2O can occur in the mid-troposphere but is negligible in the boundary layer.
Abstract: Atmospheric aerosols exert an important influence on climate through their effects on stratiform cloud albedo and lifetime and the invigoration of convective storms. Model calculations suggest that almost half of the global cloud condensation nuclei in the atmospheric boundary layer may originate from the nucleation of aerosols from trace condensable vapours, although the sensitivity of the number of cloud condensation nuclei to changes of nucleation rate may be small. Despite extensive research, fundamental questions remain about the nucleation rate of sulphuric acid particles and the mechanisms responsible, including the roles of galactic cosmic rays and other chemical species such as ammonia. Here we present the first results from the CLOUD experiment at CERN. We find that atmospherically relevant ammonia mixing ratios of 100 parts per trillion by volume, or less, increase the nucleation rate of sulphuric acid particles more than 100–1,000-fold. Time-resolved molecular measurements reveal that nucleation proceeds by a base-stabilization mechanism involving the stepwise accretion of ammonia molecules. Ions increase the nucleation rate by an additional factor of between two and more than ten at ground-level galactic-cosmic-ray intensities, provided that the nucleation rate lies below the limiting ion-pair production rate. We find that ion-induced binary nucleation of H_(2)SO_(4)–H_(2)O can occur in the mid-troposphere but is negligible in the boundary layer. However, even with the large enhancements in rate due to ammonia and ions, atmospheric concentrations of ammonia and sulphuric acid are insufficient to account for observed boundary-layer nucleation.
1,071 citations
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TL;DR: The use of nanoparticle (NP) formulations able to encapsulate molecules with therapeutic value, while targeting specific transport processes in the brain vasculature, may enhance drug transport through the BBB in neurodegenerative/ischemic disorders and target relevant regions in thebrain for regenerative processes.
955 citations
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TL;DR: Alkali-activated binders have emerged as an alternative to OPC binders, which seems to have superior durability and environmental impact as mentioned in this paper, and the proper terminology to designate these new binders will be discussed.
800 citations
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Goethe University Frankfurt1, CERN2, University of Helsinki3, Paul Scherrer Institute4, University of Beira Interior5, University of Innsbruck6, Carnegie Mellon University7, California Institute of Technology8, University of Leeds9, University of Eastern Finland10, University of Vienna11, Lebedev Physical Institute12, Finnish Meteorological Institute13, Kyoto University14, Helsinki Institute of Physics15, Stockholm University16, Leibniz Association17
TL;DR: The results show that, in regions of the atmosphere near amine sources, both amines and sulphur dioxide should be considered when assessing the impact of anthropogenic activities on particle formation.
Abstract: Nucleation of aerosol particles from trace atmospheric vapours is thought to provide up to half of global cloud condensation nuclei(1). Aerosols can cause a net cooling of climate by scattering sun ...
738 citations
Authors
Showing all 3018 results
Name | H-index | Papers | Citations |
---|---|---|---|
António Amorim | 136 | 1477 | 96519 |
João F. Mano | 97 | 822 | 36401 |
Marco Cavaglia | 93 | 372 | 60157 |
Joel J. P. C. Rodrigues | 72 | 1000 | 22175 |
Paula I. Moreira | 70 | 268 | 26670 |
Maria João Saraiva | 68 | 302 | 14775 |
Joao P. S. Catalao | 68 | 1039 | 19348 |
Paulo J. Oliveira | 66 | 530 | 18361 |
Mohamed Naceur Belgacem | 64 | 229 | 14509 |
Delfim F. M. Torres | 60 | 701 | 14369 |
Ma-Li Wong | 57 | 239 | 13708 |
Giancarlo Fortino | 55 | 511 | 12119 |
Javier Contreras | 54 | 271 | 11153 |
Pedro Oliveira | 54 | 566 | 10818 |
Ana M. Sebastião | 54 | 235 | 10285 |