Journal ArticleDOI
Total synthesis of maytansine
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This article is published in Journal of the American Chemical Society.The article was published on 1980-10-01. It has received 90 citations till now. The article focuses on the topics: Total synthesis.read more
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The Vinylogous Aldol and Related Addition Reactions: Ten Years of Progress†
TL;DR: This work has shown how the influence of a functional group may be relayed to a distant point in the molecule when these two sites are connected to by conjugated unsaturated linkages, such as double and triple bonds or aromatic moieties.
Journal ArticleDOI
Recent advances in the preparation and synthetic applications of oxiranes
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Studies with trialkylsilyltriflates: new syntheses and applications
TL;DR: In this article, the synthesis and applications for three useful reagents for silylation of unreactive substrates, triisopropylsilyl, octadecyldimethylsilylsilyl triflate, and octadecycledimethyl silyl (ECS), were described.
Journal ArticleDOI
Recent developments in the maytansinoid antitumor agents.
TL;DR: New developments in this field during the last two decades include the use of maytansinoids as "warheads" in tumor-specific antibodies, preliminary metabolism studies, investigations of their biosynthesis at the biochemical and genetic level, and ecological issues related to the occurrence of such typical microbial metabolites in higher plants.
Journal ArticleDOI
Anticancer Activity of Natural Compounds from Plant and Marine Environment
TL;DR: The chemical structure of the molecules of these substances, their properties, mechanisms of action, their structure–activity relationships, along with their anticancer properties and their potential as chemotherapeutic drugs are discussed in this paper.
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