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Book ChapterDOI
Central Nervous System
Alan Peters,Deborah W. Vaughan +1 more
TL;DR: This paper used pyramidal neurons and neuroglial cells in the primary auditory cortex (area 41) of the aging rat as a basis for the following account, and referred to recent studies of their own colleagues and of other investigators as appropriate within that context.
Journal ArticleDOI
Neuron numbers and dendritic extent in normal aging and Alzheimer's disease
Paul D. Coleman,Dorothy G. Flood +1 more
TL;DR: In this article, the authors reviewed evidence regarding neuron numbers and dendritic extent in normal aging rodent, monkey and human brain and in Alzheimer's disease and concluded that neuron loss and change in dendric extent are regionally specific, and corresponding brain regions do not always change in similar ways in rodents and primates.
Journal ArticleDOI
The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting.
TL;DR: A survey of original evidence shows that histological data always supported a 1:1 ratio of glia to neurons in the entire human brain, and a range of 40–130 billion glial cells, and the current status of knowledge about the number of cells is reviewed.
Journal ArticleDOI
Neocortical cell counts in normal human adult aging.
TL;DR: Aging affects the frontal and temporal lobes more than the parietal; the salient change is shrinkage of large neurons with consequently increasing numbers of small neurons in the midfrontal and superior temporal areas.
Journal ArticleDOI
The effects of normal aging on myelin and nerve fibers: A review
TL;DR: It is now known that significant numbers of cortical neurons are not lost and other bases for the cognitive decline have been sought, and it is likely that nerve fiber loss also contributes to cognitive decline, because of the consequent decrease in connections between neurons.