Journal ArticleDOI
Structure elucidation of the glycopeptide antibiotic complex A40926
TLDR
The structure of the two factors of the novel glycopeptide antibiotic A40926 have been determined using a combination of FAB-MS, GC-MS and 1H n.r.m. studies.Abstract:
The structure of the two factors of the novel glycopeptide antibiotic A40926 have been determined using a combination of FAB-MS, GC-MS and 1H n.m.r. studies. A40926 Is a member of the vancomycin family of antibiotics and is structurally related to teicoplanin, A35512B and aridicin.read more
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Journal ArticleDOI
Carbohydrate-based mimetics in drug design: sugar amino acids and carbohydrate scaffolds.
Journal ArticleDOI
Structure-activity relationships of vancomycin-type glycopeptide antibiotics.
Journal ArticleDOI
Antibacterial activities and modes of action of vancomycin and related glycopeptides.
TL;DR: Vancomycin (21) is produced by Amycolatopsis orientalis (18) (previously designated Nocardia orientalists and Streptomyces orientalises) and is used to treat gram-positive bacterial infections.
Journal ArticleDOI
A40926, a new glycopeptide antibiotic with anti-Neisseria activity.
Beth P. Goldstein,Enrico Selva,L. Gastaldo,Marisa Berti,Rosetta Pallanza,F Ripamonti,Pietro Ferrari,Maurizio Denaro,Vittorio Arioli,Cassani Giovanni +9 more
TL;DR: A40926 was rapidly bactericidal for N. gonorrhoeae clinical isolates at concentrations equal to or slightly higher than the MIC and levels in serum were higher and more prolonged than those of an equivalent subcutaneous dose of teicoplanin, suggesting that A40926 may have potential in the therapy of gonorrhea.