Journal ArticleDOI
Studies directed towards asymmetric synthesis of levobupivacaine
Sanjeev Kumar,Uma Ramachandran +1 more
TLDR
In this article, the first catalytic asymmetric synthesis of levobupivacaine was reported, where the key step involves the asymmetric alkylation of N-benzylimine glycinamide (2b).About:
This article is published in Tetrahedron Letters.The article was published on 2005-01-03. It has received 22 citations till now. The article focuses on the topics: Enantioselective synthesis.read more
Citations
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Journal ArticleDOI
Recent advances in asymmetric phase-transfer catalysis.
Takashi Ooi,Keiji Maruoka +1 more
TL;DR: This work has shown that the use of chiral nonracemic onium salts and crown ethers as effective phase-transfer catalysts provides a reliable and general strategy for the practical asymmetric synthesis of highly valuable organic compounds.
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Recent development and application of chiral phase-transfer catalysts.
Takuya Hashimoto,Keiji Maruoka +1 more
Journal ArticleDOI
Catalytic Asymmetric Synthesis of α-Amino Acids
Carmen Nájera,José M. Sansano +1 more
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Organocatalytic synthesis of drugs and bioactive natural products
TL;DR: In this paper, the scope and limitations of organocatalytic reactions in the synthesis of biologically important molecules are discussed, and a review of the current state-of-the-art is presented.
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Reductive Amination in the Synthesis of Pharmaceuticals.
Oleg I. Afanasyev,Ekaterina A. Kuchuk,Dmitry L. Usanov,Denis Chusov,Denis Chusov,Denis Chusov +5 more
TL;DR: This Review concisely compiles information on 71 medical substances that are synthesized by reductive amination according to the principle of action and a general synthetic scheme is provided for each compound.
References
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Journal ArticleDOI
Molecular Design of a C2-Symmetric Chiral Phase-Transfer Catalyst for Practical Asymmetric Synthesis of α-Amino Acids
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Design of N-Spiro C2-Symmetric Chiral Quaternary Ammonium Bromides as Novel Chiral Phase-Transfer Catalysts: Synthesis and Application to Practical Asymmetric Synthesis of α-Amino Acids
TL;DR: The potential synthetic utility of the present method for the practical asymmetric synthesis of structurally diverse natural and unnatural alpha-amino acids has been demonstrated by its successful application to the facile asymmetric syntheses of (S)-N-acetylindoline-2-carboxylate, a key intermediate in the synthesis of the ACE inhibitor, and l-Dopa (l-3,4-dihydroxyphenylalanine) ester and its analogue.
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Myocardial Uptake of Bupivacaine: II. Pharmacokinetics and Pharmacodynamics of Bupivacaine Enantiomers in the Isolated Perfused Rabbit Heart
TL;DR: The authors conclude that the S(-)-bupivacaine exerts less detrimental effects on the isolated heart of the rabbit perfused at a constant coronary flow with protein-free buffer.
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