Journal ArticleDOI
Studies in Stereochemistry. XXX. Models for Steric Control of Asymmetric Induction1
Donald J. Cram,Karl R. Kopecky +1 more
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This article is published in Journal of the American Chemical Society.The article was published on 1959-06-01. It has received 408 citations till now. The article focuses on the topics: Steric effects.read more
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Organic Reactions in Aqueous Media with a Focus on Carbon−Carbon Bond Formations: A Decade Update
TL;DR: Reaction of R,â-Unsaturated Carbonyl Compounds 3127: Reaction of R-UnSaturated Carbonies 3127 7.1.6.
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Double Asymmetric Synthesis and a New Strategy for Stereochemical Control in Organic Synthesis
TL;DR: In this article, it is shown that double asymmetric induction can be analyzed in terms of the single asymmetric reactions of each of the two chiral reactants, and a new strategy based on this rule for the predictable creation of new chiral centers is discussed and the use of this strategy for the synthesis of sugars and macrolides is presented.
Journal ArticleDOI
Structure and Reactivity of Lithium Enolates. From Pinacolone to Selective C‐Alkylations of Peptides. Difficulties and Opportunities Afforded by Complex Structures
TL;DR: The chemistry of lithium enolates is used to demonstrate that complex structures held together by noncovalent bonds (supramolecules) may dramatically influence the result of seemingly simple standard reactions of organic synthesis as mentioned in this paper.
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Chelation or Non‐Chelation Control in Addition Reactions of Chiral α‐ and β‐ Alkoxy Carbonyl Compounds [New Synthetic Methods (44)]
TL;DR: In this article, two strategies have been developed: (1) Use of Lewisacidic reagents which form intermediate chelates, these being attacked stereoselectively from the less hindered side (chelation control); (2) use of reagents incapable of chelation, stereoselection attack being governed by electronic and/or steric factors (non-chelation Control).