Journal ArticleDOI
Studies on closure of the ductus arteriosus. XI. Ductal closure in utero by a prostaglandin synthetase inhibitor
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TLDR
Intrauterine contraction of the ductus arteriosus in fetuses followed a single oral dose of 15 mg/kg indomethacin to pregnant rats 12 or 18 h prior to delivery may be a danger to the fetus and subsequent postnatal adjustment.About:
This article is published in Prostaglandins.The article was published on 1974-12-10. It has received 112 citations till now. The article focuses on the topics: Ductus arteriosus & In utero.read more
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Journal ArticleDOI
Closure of the Ductus Arteriosus in Premature Infants by Inhibition of Prostaglandin Synthesis
TL;DR: Inhibition of prostaglandin synthesis constricts the ductus arteriosus in fetal lambs in utero and assessed the effects clinically and by echocardiography (left atrial/aortic-root ratio).
Journal ArticleDOI
Pharmacologic closure of patent ductus arteriosus in the premature infant.
William F. Friedman,Michael J. Hirschklau,Morton P. Printz,Paul T. Pitlick,Stanley E. Kirkpatrick +4 more
TL;DR: The observation that constriction and closure of the patent ductus arteriosus may be induced pharmacologically raises important possibilities for the improved treatment of the respiratory-distress syndrome.
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E-type prostaglandins: a new emergency therapy for certain cyanotic congenital heart malformations.
TL;DR: Prostaglandin E2 (PGE2) has been used to maintain patency of the ductus arteriosus in four neonates with cyanotic congenital heart disease due to obstructive right heart malformations and the same treatment may be useful preoperatively in patients with aortic interruption who also depend on continued patency for blood supply to the lower half of the body.
Journal Article
The Pharmacology of the Ductus Arteriosus
TL;DR: The ductus arteriosus is a shunt blood vessel of fetal life; it extends between the pulmonary artery and the aorta and shunts deoxygenated blood from the main pulmonary artery to the descendingAorta.
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Possible association between maternal indomethacin therapy and primary pulmonary hypertension of the newborn.
TL;DR: Experience with two neonates with disorders circulatory adjustment at birth following prenatal exposure to indomethacin indicates that indometHacin may interfere with these adjustments in man and favor the development of the serious oxygen dependency known as primary pulmonary hypertension of the newborn.
References
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Journal ArticleDOI
The response of the ductus arteriosus to prostaglandins.
F Coceani,P M Olley +1 more
TL;DR: The greater effectiveness of prostaglandins on the anoxic ductus suggests a role for these compounds in the regulation of the vessel tone during fetal life.
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Relationship between inhibition of prostaglandin synthesis and drug efficacy: support for the current theory on mode of action of aspirin-like drugs.
TL;DR: In this paper, the synthesis of prostaglandin E2 from 5,8,11,14-eicosatetraenoic acid (arachidonic acid) by bovine seminal vesicle microsomes can be inhibited by the non-steroidal anti-inflammatory agents indomethacin, naproxen, its enantiomer and aspirin.
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Aspirin and Indomethacin Prolong Parturition in Rats: Evidence that Prostaglandins Contribute to Expulsion of Foetus
TL;DR: Increase of stillbirths and adverse maternal effects in rats after administration of aspirin and indomethacin in the final days of pregnancy warns against their use in the late stages of human pregnancy.
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Delay of parturition in the rat by anti-inflammatory agents which inhibit the biosynthesis of prostaglandins.
TL;DR: Investigation of the effects of some anti-inflammatory agents on the time of onset and course of parturition in the rat found PGF2α and indomethacin to be inhibitors of prostaglandin biosynthesis.
Journal ArticleDOI
Studies on Closure of the Ductus Arteriosus
TL;DR: To investigate the role of autonomic receptors in the closure of the ductus arteriosus, full term guinea-pig fetuses were treated with phenoxybenzamine, delivered by Caesarean section, and sacrificed.