Journal ArticleDOI
Studies on fatty liver with isolated hepatocytes. II. The action of carbon tetrachloride on lipid peroxidation, protein, and triglyceride synthesis and secretion.
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TLDR
Data reported here suggest that the onset of the CCl 4 -induced decrease of lipoprotein secretion is due to a derangement of the secretory pathway.About:
This article is published in Experimental and Molecular Pathology.The article was published on 1979-02-01. It has received 126 citations till now. The article focuses on the topics: Lipid peroxidation & Lipoprotein.read more
Citations
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Journal ArticleDOI
Three models of free radical-induced cell injury.
TL;DR: Three models of free radical-induced cell injury are presented and, at least in the menadione-induced cytotoxicity, lipid peroxidation is not involved.
Journal ArticleDOI
The role of lipid peroxidation in liver damage
TL;DR: It is shown that lipid peroxidation impairs lipoprotein secretion mainly at the level of the dismission from the Golgi apparatus, rather than during their assembly, and appears to give a late and not essential contribution to the fat accumulation.
Journal ArticleDOI
Studies on lipid peroxidation in normal and tumour tissues. The Novikoff rat liver tumour.
TL;DR: The substantial increase in alpha-tocopherol relative both to total lipid and to methylene-interrupted double bonds in fatty acids is the major contributor to lipid-soluble chain-breaking antioxidant in lipid extracts of normal liver and of Novikoff tumour material.
Journal ArticleDOI
Therapeutic effect of melatonin on carbon tetrachloride-induced acute liver injury in rats.
TL;DR: Melatonin exerts a therapeutic effect on CCl4‐induced acute liver injury in rats, possibly through its antioxidant action, judging from the levels of serum transaminases, indices of liver cell damage.
Journal ArticleDOI
CCl4−induced toxicity in isolated hepatocytes: The importance of direct solvent injury
TL;DR: The data suggest that early CCl4 toxicity is adirect consequence of its solvent properties and is partially reversible; subsequent damage may be mediated by lipid peroxidation.
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Book ChapterDOI
Preparation of isolated rat liver cells.
TL;DR: This chapter discusses preparation of isolated rat liver cells by incubation of rat liver minces with pronase, which results in most of the liver parenchyma is digested, while nonparenchymal cells remain intact and can be recovered from the incubate.
Book
Free radical mechanisms in tissue injury
TL;DR: This short review of free radicals discusses certain types of free radical, such as nitroxyl-radicals and free radicals stabilized by steric or derealization features, which are stable enough to be crystallised and stored at temperatures above 0°.
Journal Article
Carbon tetrachloride hepatotoxicity
TL;DR: The knowledge that hepatic triglyceride secretion involves a dual mechanism has provided a powerful new guide for the analysis of mechanisms underlying fatty liver disease, and a central requirement of this hypothesis must be that if over supply of fatty acids is to be invoked as a significant factor in the pathogenesis of fatty liver, then the oversupply must be of sufficient magnitude and duration.