Journal ArticleDOI
Studies on the biosynthesis and degradation of sphingosine bases.
TLDR
The biosynthetic and degradation pathway taken together represent an additional route of serine transformation for the synthesis of the hydrophilic part of phospholipids.About:
This article is published in Chemistry and Physics of Lipids.The article was published on 1970-10-01. It has received 56 citations till now. The article focuses on the topics: Biosynthesis & Pyridoxal phosphate.read more
Citations
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Journal ArticleDOI
An update of the enzymology and regulation of sphingomyelin metabolism
TL;DR: The enzymes of sphingomyelin turnover release ceramide and free sphingosine from endogenous substrates, which may have implications for the participation of a sphingomelin/sphingoine cycle as another 'lipid second messenger' system.
Journal ArticleDOI
The role of sphingolipids in the process of signal transduction
Journal ArticleDOI
Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long-chain base component of sphingolipids.
TL;DR: Evidence is presented that LCB1 has been molecularly cloned and that a role for sphingolipids in sporulation is implicated by the finding that diploids homozygous for lcb1 failed to sporulate.
Journal ArticleDOI
Enzymology of long-chain base synthesis by liver: Characterization of serine palmitoyltransferase in rat liver microsomes
TL;DR: This enzyme is capable of initiating the synthesis of the major long-chain bases, as well as compounds that may constitute the unidentified bases reported in analyses of mammalian sphingolipids.
Journal ArticleDOI
Characterization of serine palmitoyltransferase activity in Chinese hamster ovary cells
TL;DR: The results establish that CHO cells, and probably others, are engaged in long-chain base synthesis de novo and that serine palmitoyltransferase activity is not regulated by the availability of such compounds in the culture media.
References
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Journal ArticleDOI
The enzymatic synthesis of sphingosine.
Roscoe O. Brady,George J. Koval +1 more
TL;DR: The present communication describes the preparation of an enzyme system obtained from brain tissue which catalyzes the synthesis of sphingosine and identifies the cofactors required for these reactions.
Journal ArticleDOI
Biosynthesis of sphingolipid bases. II. Keto intermediates in synthesis of sphingosine and dihydrosphingosine by cell-free extracts of Hansenula ciferri.
Peter E. Braun,Esmond E. Snell +1 more
TL;DR: The identity of sphingosine, not previously reported as a biosynthetic product in yeast, was further confirmed by its catalytic reduction to dihydrosphingoine and by recrystallization of its triacetyl derivative to constant specific radioactivity in the presence of unlabeled authentic carrier.
Journal ArticleDOI
The enzymatic synthesis of sphingosine. II. Further studies on the mechanism of the reaction.
Journal ArticleDOI
Biosynthesis of dihydrosphingosine in vitro.
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