Journal ArticleDOI
Study of mast cell and histamine contents of the pineal body.
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The number and distribution of mast cells were studied in pineal bodies of 16 mammalian species and it was suggested that the hypotensive action of pineal extract reported by several authors might be due to the histamine content of this gland.Abstract:
The number and distribution of mast cells were studied in pineal bodies of 16 mammalian species. In cattle, goat, monkey and guinea-pig the cells occurred in large numbers; in man, sheep, marmoset and mouse there was a moderate amount, and they were almost absent in pineal bodies of horse, rat, pig, dog, hamster, fox, cat and rabbit. In 17 human pineal bodies, 11 of which were obtained from normal individuals, the mast cell population was 3 ± 0.5 mast cells per microscopical field (0.32 mm in diameter). The histamine content in pineal bodies of several mammals was also determined. The substance occurred in high amount in the pineal body of cattle, in moderate amount in that of goat, man and sheep, and could not be detected in horse, pig, rabbit and rat. In human and cattle pineal bodies the histamine content could be correlated to the mast cell population; in other species the same correlation was only suggested. In in vitro experiments octylamine released histamine from the pineal body of cattle, while compound 48/80 was ineffective. It is suggested that the hypotensive action of pineal extract reported by several authors might be due to the histamine content of this gland.read more
Citations
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Book ChapterDOI
Mast cells in the nervous system.
TL;DR: It is likely that biogenic amines released from mast cells can influence the permeability of the vasa nervorum and thereby contribute to the development of edema accompanying certain injuries to peripheral nerves.
Book ChapterDOI
The Pineal Organ
TL;DR: After decades of contradictory results, experimental paradigms have finally been developed which provide compelling evidence that secretions of the mammalian pineal organ physiologically control several neuroendocrine functions, principally involving the anterior pituitary gland and its peripheral “target organs.”
Book ChapterDOI
The Mammalian Pineal Organ
TL;DR: This survey is based on selected data from the large literature as well as on own observations and discusses aspects of pineal phylogenetic and ontogenetic development, the fine structure of the mammalian pineal, its biochemistry and physiology.
Book ChapterDOI
The mammalian pineal gland and its control of hypothalamic activity
Kappers Ja,Smith Ar,de Vries Ra +2 more
TL;DR: This chapter hesitates to consider the mammalian pineal to be an endocrine organ in the classical sense, because till now, there is not a single pineal compound fulfilling all of the criteria of a pineal hormone.
References
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Journal ArticleDOI
The presence of histamine in tissue mast cells.
J. F. Riley,G. B. West +1 more
TL;DR: Evidence that substantial amounts of histamine are contained in, and can be released by, tissue mast cells is presented in this paper, and that for certain tissues a good correlation between the histamine content and the heparin content is found.
Journal ArticleDOI
5-Hydroxytryptamine in mast cells.
TL;DR: 5-Hydroxytryptamine as well as histamine and heparin was demonstrated to be present in purified mast cells from the peritoneal washings of rats, matching that found in the mast cells of the subcutaneous areolar tissue of rats.
Journal ArticleDOI
Reduction of tissue histamine by compound 48/80.
W. Feldberg,J. Talesnik +1 more
TL;DR: Local and general reduction of tissue histamine could be obtained in several organs such as skin and skeletal muscle, and it was found that restoration to normal histamine level was a slow process.
Journal ArticleDOI
Serotonin and Histamine in Mast Cells
Journal ArticleDOI
Effects of anaphylactic shock and compound 48/80 on the mast cells of the guinea pig lung.
Ivan Mota,Itamar Vugman +1 more
TL;DR: It is found that similar changes can be produced in guinea pig lung mast cells by means of anaphylactic shock, but not by the action of compound 48/80.