Journal ArticleDOI
Substance P effects on spinal nociceptive neurones.
TLDR
Results indicate that substance P facilitates nociceptive pathways by potentiating the subliminal fringe and, in greater amounts, by depolarizing the cells.About:
This article is published in Life Sciences.The article was published on 1979-06-04. It has received 77 citations till now. The article focuses on the topics: Noxious stimulus & Stimulation.read more
Citations
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Journal ArticleDOI
Neurotransmitter candidates of somatosensory primary afferent fibres.
Thomas E. Salt,R.G. Hill +1 more
Journal ArticleDOI
Emerging Concepts in the Neurobiology of Chronic Pain: Evidence of Abnormal Sensory Processing in Fibromyalgia
TL;DR: During the past decade, an exponential growth has occurred in the scientific underpinnings of chronic pain states, and the concept of nonnociceptive pain has been refined at a physiologic, structural, and molecular level.
Journal ArticleDOI
Slow excitatory transmission in rat dorsal horn: possible mediation by peptides
Laszlo Urban,Mirjana Randić +1 more
TL;DR: Repetitive stimulation of a dorsal root elicited a slow depolarization in about half of the dorsal horn neurons examined in the rat spinal cord slice preparation, which was markedly depressed or abolished in the presence of substance P, substance P antagonists and capsaicin.
Journal ArticleDOI
Effects of iontophoretically released amino acids and amines on primate spinothalamic tract cells.
TL;DR: The results suggest that GABA, Gly, 5-HT, NE, and DA may be inhibitory neurotransmitters on nociceptive STT cells.
Book ChapterDOI
Substance P in the Nervous System
TL;DR: The properties of a vasodepressor substance extracted from brain and intestine and originally called preparation P were first described by von Euler and Gaddum in 1931 and are surprisingly difficult to cite a single physiologically relevant action of substance P.
References
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Journal ArticleDOI
Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons.
TL;DR: The present results give strong evidence for the occurrence of SP in a certain population of primary sensory neurons and support earlier findings that SP may act as a transmitter or modulator in these neurons.
Journal ArticleDOI
Opiate analgesics inhibit substance P release from rat trigeminal nucleus.
T. M. Jessell,L. L. Iversen +1 more
TL;DR: It is reported here that opiate analgesics are able to suppress the stimulus-evoked release of SP, which may represent a mechanism for the direct spinal analgesic actions of opiates.
Journal ArticleDOI
Effects of substance P on functionally identified units in cat spinal cord
TL;DR: Results suggest that substance P may be involved in excitatory spinal processes and that its actions may be associated specifically with nociception.
Journal ArticleDOI
Capsaicin-induced depletion of substance P from primary sensory neurones.
TL;DR: Observations strongly support the concept that substance P acts as a primary sensory transmitter and the administration of capsaicin, which is known to desensitize peripheral receptors responding to painful chemogenic stimuli, virtually abolishes the fluoride-resistant acid phosphatase activity of the substantia gelatinosa.
Journal ArticleDOI
Neurotransmitters decrease the calcium component of sensory neurone action potentials
TL;DR: With the thought that modulation of Ca2+ currents may be a general correlate of presynaptic inhibition, the effect of several putative neurotransmitters on the soma spike of cultured chick sensory neurones are studied, and they decrease the calcium component of cell body action potentials.