Journal ArticleDOI
Supercritical fluid fabrication of components for a sustained-release injectable risperidone dose form
V. N. Bagratashvili,S. E. Bogorodskii,Alexey M. Egorov,L. I. Krotova,Vladimir K. Popov,V. I. Sevast’yanov +5 more
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TLDR
In this paper, the process of supercritical fluid encapsulation of pharmaceutical grade risperidone into bioresorbable D,L-polylactide microparticles via the Particles from Gas-Saturated Solutions (PGSS) method was examined.Abstract:
The process of supercritical fluid encapsulation of pharmaceutical grade risperidone into bioresorbable D,L-polylactide microparticles via the PGSS (Particles from Gas-Saturated Solutions) method was examined. Micronization and changes in the morphology of risperidone crystals during its encapsulation into a polymer plasticized with supercritical carbon dioxide were experimentally observed. This result made it possible to prepare the polymer structures of various dispersities (from 10 to 100 μm) and morphologies containing up to 40 wt % of risperidone without the use of organic solvents. The kinetics of release of risperidone from polymer microparticles in saline solution was studied by UV spectrophotometry. It was shown that the use of D,L-polylactides of various molecular weights makes it possible to achieve a controlled increase in the time of release of risperidone from bioresorbable polymer particles prepared via the PGSS technique up to ten days.read more
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Journal ArticleDOI
Physicochemical Properties of the Inclusion Complex of Moxifloxacin with Hydroxypropyl-β-Cyclodextrin Synthesized by RESS
TL;DR: In this paper, a new method for the synthesis of guest-host inclusion complex of moxifloxacin (MF) with 2-hydroxypropyl-β-cyclodextrin (HPCD) by supercritical fluid technology in the rapid expansion of supercritical solutions (RESS) mode was suggested for developing new drug formulations with improved bioaccessibility.
Journal ArticleDOI
A method to slow down the ionization-dependent release of risperidone loaded in a thermoresponsive poly( N -acryloyl glycinamide) hydrogel
Mahfoud Boustta,Michel Vert +1 more
TL;DR: In order to minimize the ionization and thus the solubility of the drug inside the hydrogel despite outside buffering at 7.4, Mg(OH2), a sparingly soluble mineral base, was added to the standard formulation and resulted in a c.a. threefold increase of the zero-order release duration.
Journal ArticleDOI
PLGA Carriers for Controlled Release of Levofloxacin in Anti-Tuberculosis Therapy
Evgeny N. Antonov,Sofya Andreevskaya,I. V. Bocharova,S. E. Bogorodsky,L. I. Krotova,Elena Larionova,Alexandra Olegovna Mariyanats,Gennady V. Mishakov,Tatiana Smirnova,Larisa Chernousova,Vladimir K. Popov +10 more
TL;DR: Results make it possible to consider the developed compositions as a promising candidate for anti-tuberculosis control release formulations providing for the further evaluation of their activity against Mtb and their metabolism in vivo over long periods of tuberculosis infection.
Journal ArticleDOI
Development of Components of Prolonged Action Antibacterial Dosage Forms Using SCF Technologies
E. N. Antonov,S. E. Bogorodsky,A. G. Dunaev,L. I. Krotova,A. O. Mariyanats,M. A. Syachina,Vladimir K. Popov +6 more
TL;DR: Gentamicin and levofloxacin are encapsulated into bioresorbable polymer scaffolds and microparticles by the SCF methods: particles from gas saturated solutions (PGSS) and plasticization, with the subsequent foaming of amorphous polymers using supercritical carbon dioxide.
References
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Journal ArticleDOI
Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates.
TL;DR: The concept and theory of crystal engineering is covered and the potential benefits, disadvantages and methods of preparation of co-crystals, metastable polymorphs, high-energy amorphous forms and ultrafine particles are discussed.
Journal ArticleDOI
Micronization by Rapid Expansion of Supercritical Solutions to Enhance the Dissolution Rates of Poorly Water-Soluble Pharmaceuticals
TL;DR: In this article, the dissolution rate of racemic ibuprofen in supercritical CO2 was measured using a dynamic apparatus at pressures between 80 and 220 bar and temperatures of 35, 40, and 45 °C.
Journal ArticleDOI
Supercritical fluid mixing: preparation of thermally sensitive polymer composites containing bioactive materials
Steven M. Howdle,Michael S. Watson,Martin J. Whitaker,Vladimir K. Popov,Martyn C. Davies,Frederick S. Mandel,J. Don Wang,Kevin M. Shakesheff +7 more
TL;DR: In this article, the use of supercritical carbon dioxide (scCO2) to create a diverse range of polymeric composites was reported, incorporating thermal and solvent labile guest materials such as proteins.
Journal ArticleDOI
Risperidone : a review of its pharmacology and therapeutic potential in the treatment of schizophrenia
Susan M. Grant,Andrew Fitton +1 more
TL;DR: Advantages offered by risperidone over haloperidol include a faster onset of antipsychotic action, a lower incidence of extrapyramidal effects and possibly greater efficacy against the negative symptoms of schizophrenia.
Journal ArticleDOI
Are pharmaceutics really going supercritical
Irene Pasquali,Ruggero Bettini +1 more
TL;DR: The present work focuses on some applications of supercritical fluids in the pharmaceutical field, provides a critical review of the most recent advances and aims to give a vision on the future of this technology.
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