Journal ArticleDOI
Sympatho-adrenal responses of spontaneously hypertensive rats to immobilization stress
TLDR
It is demonstrated that adaptive changes in the cardiovascular and sympatho-adrenal medullary systems of repeatedly immobilized rats are greater in SHR than in WKY rats.Abstract:
Blood pressure, heart rate, and circulating levels of norepinephrine, epinephrine, and corticosterone were measured before and during the first or seventh period of immobilization stress (150 min per day) in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) normotensive male rats. A catheter was inserted into the tail artery of each rat to permit direct measurement of blood pressure and heart rate and serial sampling of blood in conscious, unhandled animals. During the first immobilization, SHR rats had significantly higher circulating levels of norepinephrine, epinephrine, and corticosterone than did WKY rats. One day after the sixth immobilization, basal levels of norepinephrine and epinephrine were significantly higher and mean blood pressure was significantly lower in repeatedly stressed SHRs compared to unstressed SHRs. In addition, adaptation to the repeated stress in SHRs was attended by reduced adrenomedullary secretion and an increased blood pressure response. These results demonstrate that adaptive changes in the cardiovascular and sympatho-adrenal medullary systems of repeatedly immobilized rats are greater in SHR than in WKY rats.read more
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Journal ArticleDOI
Similarities of genetic (spontaneous) hypertension. Man and rat.
N C Trippodo,E D Frohlich +1 more
TL;DR: The affirmative position that the SHR is, indeed, an excellent model for the study of essential hypertension is taken, however, with four important caveats.
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Stress-induced expression of immediate early genes in the brain and peripheral organs of the rat
Emiko Senba,Takashi Ueyama +1 more
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Comparison of the behavioural and endocrine response to forced swimming stress in five inbred strains of rats
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Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. II. Adaptation to chronically presented stressful stimuli.
TL;DR: Results provide further support for the hypothesis that tonic elevations in LC neuronal activity are stress related and that the LC is involved in the CNS response to challenges to the organism.
Journal ArticleDOI
Angiotensin II AT1 receptor blockade ameliorates brain inflammation.
Julius Benicky,Enrique Sanchez-Lemus,Masaru Honda,Tao Pang,Martina Orecna,Juan Wang,Yan Leng,De-Maw Chuang,Juan M. Saavedra +8 more
TL;DR: The results demonstrate that systemic administration of the centrally acting angiotensin II AT1 receptor blocker (ARB) candesartan to normotensive rats decreases the acute brain inflammatory response to Administration of the bacterial endotoxin lipopolysaccharide (LPS), a model of brain inflammation.
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