Syntheses of 2-Hydroxymethylnicotinic Acid Lactone, 2-Hydroxymethylpyridine-3-acetic Acid Lactone, and Some of their Derivatives
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In this article, pyridine lactones were prepared from 2-methylnicotinic acid using 2-hydroxymethylnaphthyridine derivatives, which were then reduced with lithium aluminium hydride, yielding pyrrolopyridine and 1, 7 naphthiridine derivatives with a fair degree of hypotensive action.Abstract:
New type 2, 3-disubstituted pyridine lactones were prepared from 2-methylnicotinic acid The lactones, 2-hydroxymethylnicotinic acid lactone and 2-hydroxymethylpyridine-3-acetic acid lactone, were reacted with various amines to form the corresponding lactams, and the lactams were reduced with lithium aluminium hydride, yielding pyrrolopyridine and 1, 7-naphthyridine derivatives which possessed a fair degree of hypotensive actionread more
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Journal ArticleDOI
Prospects for stereocontrol in the reduction of aromatic compounds
Book ChapterDOI
Recent Developments in Naphthyridine Chemistry
TL;DR: In this paper, a review on the chemistry of naphthyridines is presented, which provides an illustration of reactions on nitrogen N-alkyl derivatives, N-amino derivatives, and N-oxides.
Patent
Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof
TL;DR: The present disclosure provides compounds that function as modulators of aldehyde dehydrogenase (ALDH) enzymatic activity, as well as compositions and formulations comprising the compounds.
Journal ArticleDOI
Cyclobutene ring-opening of bicyclo[4.2.0]octa-1,6-dienes: access to CF3-substituted 5,6,7,8-tetrahydro-1,7-naphthyridines.
Artur K. Mailyan,Alexander S. Peregudov,Pierre H. Dixneuf,Christian Bruneau,Sergey N. Osipov +4 more
TL;DR: An efficient method based on unusual cyclobutene ring-opening of bicyclo[4.2.0]octa-1,6-dienes with pyrrolidine to afford the corresponding 1,5-diketones followed by their heterocyclization has been developed.