Journal ArticleDOI
synthesis and biological activity of 4-methyl-3,5-dioxane derivatives as thromboxane a2 receptor antagonists
Hiroshi Marusawa,Hiroyuki Setoi,Akio Kuroda,Akihiko Sawada,Jiro Seki,Yukio Motoyama,Hirokazu Tanaka +6 more
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TLDR
Several compounds were found to be potent TXA2 receptor antagonists and compound 8b was the most effective inhibitor of 9,11-epoxymethano PGH2 (U-46619)-induced human platelet aggregation.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 1999-11-01. It has received 11 citations till now.read more
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Syntheses and evaluation of antioxidant activity of sydnonyl substituted thiazolidinone and thiazoline derivatives
Mei-Hsiu Shih,Fang-Ying Ke +1 more
TL;DR: Among these compounds, 4-methyl-2-[(3-arylsydnon-4-yl-methylene)hydrazono]-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester and 4-phenyl-2 exhibit the potent DPPH (1,1-diphenyl- 2-picrylhydrazyl) radical scavenging activity, comparable to that of vitamin E.
Journal ArticleDOI
Protein-protein interactions as a target for drugs in proteomics
Alexander I. Archakov,Vadim M. Govorun,Alexander V. Dubanov,Yuri D. Ivanov,Alexander V. Veselovsky,Paul J. Lewi,Paul A. J. Janssen +6 more
TL;DR: This review highlights the methods of bioinformatics and functional proteomics of protein‐protein interaction investigation, and the contact surfaces of temporary protein complexes have unique structure and properties and they represent prospective targets for a new generation of drugs.
Journal ArticleDOI
Protein–protein interactions: mechanisms and modification by drugs
Alexander V. Veselovsky,Yu. D. Ivanov,Andrew Ivanov,Alexander I. Archakov,Paul J. Lewi,Paul A. J. Janssen +5 more
TL;DR: The contact surfaces of the protein complexes have unique structure and properties, so they represent prospective targets for a new generation of drugs.
Journal ArticleDOI
Syntheses of Aromatic Substituted Hydrazino-thiazole Derivatives to Clarify Structural Characterization and Antioxidant Activity between 3-Arylsydnonyl and Aryl Substituted Hydrazino-thiazoles
TL;DR: Results of this study demonstrate that not only the thiazole ring and the aryl ring has the contribution to the antioxidant activities, the sydnone ring of 3-arylsydnonyl moiety also has its considerable contribution.
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Efficient syntheses of thiadiazoline and thiadiazole derivatives by the cyclization of 3-aryl-4-formylsydnone thiosemicarbazones with acetic anhydride and ferric chloride
Mei-Hsiu Shih,Cheng-Ling Wu +1 more
TL;DR: In this paper, the precursors of sydnonyl-substituted heterocycles were cycled with acetic anhydride to obtain 4-acetyl-2-phenylamino-5-(3-arylsydnon-4-yl)-4,5-dihydro-[1,3,4]thiadiazoles 6e−h in high yield.
References
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Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.
TL;DR: Evidence is presented that the more unstable and major component of rabbit aorta contracting substance (RCS) formed in platelets and guinea pig lung is also thromboxane A2.
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Cloning and expression of cDNA for a human thromboxane A2 receptor
Masakazu Hirata,Yasunori Hayashi,Fumitaka Ushikubi,Yoshifumi Yokota,Ryoichiro Kageyama,Shigetada Nakanishi,Shuh Narumiya +6 more
TL;DR: This first report on the molecular structure of an eicosanoid receptor will promote the molecular pharmacology and pathophysiology of these bioactive compounds.
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Coronary arterial smooth muscle contraction by a substance released from platelets: evidence that it is thromboxane A2.
TL;DR: The contraction produced by aggregating platelets was unlike those produced by prostaglandins E2, F2alpha, G2, or H2, but resembled that evoked by thromboxane A2, which is formed by platelets during aggregation.
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Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations
TL;DR: It is suggested that U‐46619 is a selective TxA2‐mimetic and that it should therefore be a valuable tool in the study of the actions of TXA2.
Journal Article
Pharmacological actions of SQ 29,548, a novel selective thromboxane antagonist.
TL;DR: Inhibition of platelet function by +/- SQ 29,548 was not associated with inhibition of cyclooxygenase or thromboxane synthetase or with changes in platelet cyclic AMP.