Journal ArticleDOI
Synthesis of pyridazine derivatives—XVI : Methyl substituted imidazo(1.2-b)pyridazines by synthesis and homolytic methylation
TLDR
Several Me substituted imidazo[1.2-b]pyridazines have been synthesized and NMR data for some of them are included and discussed in this paper.About:
This article is published in Tetrahedron.The article was published on 1968-01-01. It has received 19 citations till now. The article focuses on the topics: Pyridazine & Homolysis.read more
Citations
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Patent
Fused heterocyclic compounds useful as kinase modulators
Wayne Vaccaro,Zhong Chen,Dharmpal S. Dodd,Tram N. Huynh,James Lin,Chunjian Liu,Mussari Christopher P,John S. Tokarski,David R. Tortolani,Stephen T. Wrobleski +9 more
TL;DR: In this paper, the authors defined a class of compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically acceptable salts, and hydrates, thereof, which are useful as kinase modulators, including MK2 modulation.
Journal ArticleDOI
Synthesis of imidazo[1,2‐b]pyridazines: Fenbendazole, oxifenbendazole analogs and related derivatives
TL;DR: A series of imidazo[1,2-b]pyridazines has been prepared and evaluated for macrofilaricidal activity against Brugia pahangi or Acanthocheilonema viteae infections in jirds and none of these compounds possessed significant activity against human cytomegalovirus (HCMV) or filarial infections.
Journal ArticleDOI
Research on heterocyclic compounds. XX. Synthesis of trifluoromethyl derivatives of fused imidazole systems
TL;DR: A series of heterocyclic compounds having an imidazole ring fused with another ring with a bridgehead nitrogen atom and bearing a trifluoromethyl moiety was synthesized by reaction of 3-bromo-1, 1, 1-trifluoroacetone with various heteroarylamines as mentioned in this paper.
Journal ArticleDOI
Synthesis of pyridazine derivatives XXII. s‐triazolo[4, 3‐b]pyridazine 5‐oxides
TL;DR: In this article, the synthesis of s-triazolo[4,3-b] pyridazine 5-oxides with a bridgehead nitrogen has been reported.
Patent
6-cycloamino-3-(pyrid-4-yl)imidazo[1,2-b]pyridazine derivatives, preparation thereof and therapeutic use thereof
Almario Garcia Antonio,Barrague Matthieu,Burnier Philippe,Cécile Enguehard-Gueiffier,Gao Zhongli,George Pascal,A. Gueiffier,Adrien Tak Li,Puech Frederic,Roy Vaz,Qiuxia Zhao +10 more
TL;DR: In this article, the 6-cycloamino-3-(pyridin-4-yl)imidazo derivatives corresponding to general formula (I): wherein R2, R3, R7, R8, A, L and B are as defined as defined in this paper.
References
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Journal ArticleDOI
N.m.r. Studies of Pyrimidine, Imidazole and their Monomethyl Derivatives
Journal ArticleDOI
Synthesis of pyridazine derivatives—VIII : Imidazo(1,2,-b)pyridazines and some tricyclic aza analogs
Branko Stanovnik,Miha Tišler +1 more
TL;DR: In this article, the derivatives of a new azaheterocycle, imidazo(1,2-b)s-triazolo(3,4-f)pyridazine (V) and its derivatives have been used for convenient syntheses of new heterocyclic systems.
Journal ArticleDOI
Synthesis in the Pyridazine Series. II. The Preparation of Pyridazines from Substituted Maleic Anhydrides. Some Properties of 4-Methylpyridazine1
R. H. Mizzoni,Paul E. Spoerri +1 more
Journal ArticleDOI
NMR spectra and π-electron densities of some imidazo(1,2-a) pyridines
W.W. Paudler,H. L. Blewitt +1 more
TL;DR: In this article, the NMR spectra of tenπ-electron nitrogen heterocylic compounds, imidazo(1,2-a)pyridine and several of its mono-and dialkylated derivatives were analyzed and a qualitative correlation between the proton chemical shifts and the πelectron densities of the carbon atoms bearing these protons was discussed.
Journal ArticleDOI
Synthesis of pyridazine derivatives—XV: Some electrophilic substitutions on imidazo[1,2-b]-pyridazines
TL;DR: In this paper, NMR data for several imidazo[1,2-b]pyridazines are included and from these conclusive evidence is obtained that electrophilic substitution occurs at position 3.
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Synthesis of pyridazine derivatives—XV: Some electrophilic substitutions on imidazo[1,2-b]-pyridazines
Synthesis of pyridazine derivatives—VIII : Imidazo(1,2,-b)pyridazines and some tricyclic aza analogs
Branko Stanovnik,Miha Tišler +1 more