Journal ArticleDOI
Synthesis of the ABC ring system of brevetoxin B
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La synthese du squelette pyranno [2,3b] pyranne de la brevetoxine B est effectuee; le compose obtenu comporte un phosphonium quaternaire as discussed by the authors.Abstract:
La synthese du squelette pyranno [2,3-b] pyranne de la brevetoxine B est effectuee; le compose obtenu comporte un phosphonium quaternaireread more
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Solid-phase oligosaccharide synthesis and combinatorial carbohydrate libraries.
TL;DR: This work focuses on the development of Carbohydrate Libraries in Solution Using Thioglycosides from Multistep Synthesis to Programmable, One--Pot Synthesis and its Application to Solid--Phase Oligosaccharide Synthesis.
Journal ArticleDOI
Adventures in Carbohydrate Chemistry: New Synthetic Technologies, Chemical Synthesis, Molecular Design, and Chemical Biology
TL;DR: The field of carbohydrate chemistry has occupied the minds and hearts of many scientists for over a hundred years and, as we enter the twenty-first century, it continues to be both vigorous and challenging.
Journal ArticleDOI
A general strategy for stereoselective glycosylations.
TL;DR: The use of the new methodology in combination with traditional neighboring group participation by esters to introduce beta-glycosides makes it possible, for the first time, to synthesize a wide variety of oligosaccharides by routine procedures.
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Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides.
Gary H. Posner,Paul M. O'Neill +1 more
TL;DR: Evidence is reviewed elucidating the mechanism of iron-induced triggering of antimalarial trioxanes and how incorporating metabolism-blocking substituents provides some new, potent, semi-synthetic artemisinin derivatives.
Journal ArticleDOI
Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance
Kyriacos C. Nicolaou,Kyriacos C. Nicolaou,Christopher R. H. Hale,Christian Nilewski,Heraklidia A. Ioannidou +4 more
TL;DR: In the last few decades a surge in total synthesis endeavors around the world led to a remarkable collection of achievements that covers a wide ranging landscape of molecular complexity and diversity.