Journal ArticleDOI
Testing beyond ethnomedical claims: Brine shrimp lethality of some Tanzanian plants
TLDR
The results indicate the possibility that some of the plant extracts may be toxic or contain useful cytotoxic compounds, which was not reported by the traditional healers.Abstract:
Extracts of 34 plants that are traditionally used for the treatment of different diseases exhibited various degrees of toxicity on brine shrimp. The concentration killing 50% (LC50) of the shrimps was below 50 μg/ml for 14 (41.2%), 50–100 μ g/ml for 10 (29.4%), and greater than 100 μg/ml for 10 (29.4%) of the plants, respectively. Dalbergia nitidula (LC50 0.87 μg/ml), Ozoroa insignis (LC50 2.21 μg/ml), Markhamia obtusifolia (LC50 8.94 μg/ml), Ximenia caffra (LC50 11.25 μg/ml),Croton macrostachys (LC50 13.40 μg/ml), and Mormodica calantha (LC50 19.38 μg/ml) were the most toxic. The results indicate the possibility that some of the plant extracts may be toxic or contain useful cytotoxic compounds, which was not reported by the traditional healers.read more
Citations
More filters
Journal ArticleDOI
Brine shrimp toxicity of some plants used as traditional medicines in Kagera Region, north western Tanzania.
Mainen J. Moshi,E. Innocent,Joseph J. Magadula,Donald F Otieno,Anke Weisheit,Pamela K Mbabazi,Ramadhani S O Nondo +6 more
TL;DR: The results indicate that among the 30 plants used as traditional medicines, 28 are safe for short term use and mildly toxic Picralima nitida and Rubus rigidus extracts are mildly toxic, but by comparison have a remote possibility to yield active anticancer compounds.
Journal ArticleDOI
Recognition and development of traditional medicine in Tanzania.
TL;DR: It is indicated that TM is the most common form of health care, and that the HIV pandemic has highlighted the need to work across health sectors, and it is yet to be seen if the recent regulations can be made fully operational and implemented.
Journal ArticleDOI
In vitro anti-plasmodial and in vivo anti-malarial activity of some plants traditionally used for the treatment of malaria by the Meru community in Kenya
James W. Gathirwa,James W. Gathirwa,G.M. Rukunga,Eliud N.M. Njagi,Sabah A. Omar,Anastasia N. Guantai,C.N. Muthaura,Peter Mwitari,C.W. Kimani,Peter G. Kirira,Festus M. Tolo,Teresia N. Ndunda,Isaiah O. Ndiege +12 more
TL;DR: The plants with high in vitro anti-plasmodial (low IC50 values) and high anti-malarial activity (high chemo-suppression) in vivo are potential sources of novel anti- malarial drugs.
Journal ArticleDOI
Comparison of bioassays using the anostracan crustaceans Artemia salina and Thamnocephalus platyurus for plant extract toxicity screening
TL;DR: Este estudo revelou que T. platyurus e teste promissor para uma investigacao aprofundada na selecao de extratos de plantas com potenciais propriedades medicinais foram substancialmente inferiores aos da especie de teste de agua salgada.
Journal ArticleDOI
Ethnopharmacological Uses, Phytochemistry, and Pharmacological Properties of Croton macrostachyus Hochst. Ex Delile: A Comprehensive Review
TL;DR: Pharmacological studies on C. macrostachyus indicate that it has a wide range of pharmacological activities such as anthelmintic, antibacterial, antimycobacterial, antidiarrhoeal, antifungal, anticonvulsant and sedative, antiidiabetic, anti-inflammatory, antileishmanial, antioxidant, antiplasmodial, and larvicidal effects.
References
More filters
A simplified method of evaluating dose-effect experiments.
J. T. Litchfield,F Wilcoxon +1 more
TL;DR: The method provides means for the rapid test of parallelism of two curves and easy computation of relative potency with its confidence limits and its accuracy is commensurate with the nature of dose-per cent effect data.
Journal Article
A simplified method of evaluating dose-effect experiments
J. T. Litchfield,F Wilcoxon +1 more
TL;DR: In this article, a rapid graphic method for approximating the median effective dose and the slope of dose-per-cent effect curves is presented, and confidence limits of both of these parameters for 19/20 probability are given by the method.
Journal ArticleDOI
Brine shrimp: a convenient general bioassay for active plant constituents.
Brian N. Meyer,Nelson R. Ferrigni,J. E. Putnam,Linda B. Jacobsen,David E. Nichols,Jerry L. McLaughlin +5 more
TL;DR: Screening results with seed extracts of 41 species of Euphorbiaceae were compared with 9KB and 9PS cytotoxicities and the method is rapid, reliable, inexpensive, and convenient as an in-house general bioassay tool.
A convenient general bioassay for active plant constituents
Brian N. Meyer,Nelson R. Ferrigni,J. E. Putnam,J B Jacobson,D E Nicholas,Jerry L. McLaughlin,B Shrimp +6 more
TL;DR: In this article, a simple bioassay for natural product research using brine shrimp (Artemia salina leach) is proposed, which determines LC (50) values in microg/ml of active compounds and extracts in the brine medium.
Journal ArticleDOI
The Ethnobotanical Approach to Drug Discovery
Paul Alan Cox,Michael J. Balick +1 more