Testosterone-induced depletion of thymus and marrow lymphocytes as related to lymphopoiesis and hematopoiesis.
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Testosterone administration to normal male and female rats causes increased erythropoiesis and granulocytosis at the same time that bone marrow and thymus lymphocytic cellularity is being diminished as discussed by the authors.About:
This article is published in Blood.The article was published on 1970-03-01 and is currently open access. It has received 47 citations till now. The article focuses on the topics: Bone marrow & Lymphopoiesis.read more
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Cerebral lateralization. Biological mechanisms, associations, and pathology: II. A hypothesis and a program for research.
TL;DR: The hypothesis is that slowed growth within certain zones of the left hemisphere is likely to result in enlargement of other cortical regions, in particular, the homologous contralateral area, but also adjacent unfaffected regions.
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Left-handedness: association with immune disease, migraine, and developmental learning disorder.
Norman Geschwind,Peter O. Behan +1 more
TL;DR: An experimental study designed to test the following hypothesis derived from clinical observations: There is an elevated frequency in left-handed individuals and in their families of immune disease, migraine, and developmental learning disorders and finds markedly higher frequencies in the left- handers than in the right-handers.
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Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action
TL;DR: The possibility of using sex hormone modulation of immune responses for the treatment of autoimmune disorders is a promising area for future investigation.
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Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in nzb/nzw f1 mice.
TL;DR: Mice receiving androgen showed improved survival, reduced anti-nucleic acid antibodies, or less evidence of glomerulonephritis as determined by light, immunofluorescent, and electron microscopy, while opposite effects were observed in castrated mice receiving estrogen.
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Suppressive effects of androgens on the immune system.
TL;DR: The importance of testosterone in down-regulating the systemic immune response by cell type specific effects in the context of immunological disorders is highlighted, leading the way to the identification of novel therapeutic targets for immune disorders.
References
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Current concepts of the immunological function of the thymus.
TL;DR: Discriminant spleen assays performed in thymectomized mice recieved negative results on the basis of EMT or “cell reprograming,” respectively.
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Effect of Hormones on Lymphatic Tissue
TL;DR: The author has found it impossible to present more than a few of the vast number of facts available in the literature concerning the hormonal control of lymphatic tissue.
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The immunological role of different lymphoid organs in the chicken. I. Dissociation of immunological responsiveness.
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The Failure Of Thymus-derived Cells To Produce Antibody
TL;DR: The capacities of cells of thymus and bone marrow origin taken from radiation chimaeras to produce antibody during a secondary immune response have been tested in an in vivo transfer system and it could be shown that thymUS-derived cells respond vigorously by mitosis to antigenic stimulation they were not capable of antibody production.
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Testosterone-induced remission in aplastic anemia of both acquired and congenital types. Further observations in 24 cases.
TL;DR: Most children with this disease die from anemia, hemorrhage or infection, despite treatment with antimicrobial drugs, corticosteroids and .