Journal ArticleDOI
The Addition of Organomagnesium Halides to Pseudocodeine Types. II. Preparation of Nuclear Alkylated Morphine Derivatives1
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This article is published in Journal of the American Chemical Society.The article was published on 1936-08-01. It has received 29 citations till now.read more
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Kappa opioids and the modulation of pain.
TL;DR: The pharmacological profile of Kop agonists in visceral pain models suggest that peripherally restricted KOP agonists are potentially useful for a variety of peripheral pain states.
Journal ArticleDOI
Salvinorin A Analogs as Probes in Opioid Pharmacology
TL;DR: The opium poppy, Papaver somniferum, is one of several plants that have profoundly affected human history and provided an unmatched medicine for the relief of pain for centuries.
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DARK Classics in Chemical Neuroscience: Morphine.
TL;DR: The history of morphine is detailed, from the first extraction and isolation by Sertürner in 1804 to the illicit use of morphine and proliferation of opioid use and abuse disorders currently ravaging the United States.
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Recent developments in the chemistry of thebaine and its transformation products as pharmacological targets.
TL;DR: This review intends to focus on chemical transformations of morphinans which resulted in morphinandiene derivatives with well-established and novel pharmacological potencies.
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Morphinans and isoquinolines: acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors.
Daniela Schuster,Mariana Spetea,Melisa Music,Silvia Rief,Monika Fink,Johannes Kirchmair,Johannes Schütz,Gerhard Wolber,Thierry Langer,Hermann Stuppner,Helmut Schmidhammer,Judith M. Rollinger +11 more
TL;DR: Following indications from pharmacophore-based virtual screening of natural product databases, morphinan and isoquinoline compounds were tested in vitro for acetylcholinesterase (AChE) inhibition and the enrichment of actives was significantly higher than in a random selection of test compounds.