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Journal ArticleDOI

The anti‐inflammatory effect of some immunosuppressive agents

J. E. Stevens, +1 more
- 01 Feb 1969 - 
- Vol. 97, Iss: 2, pp 367-373
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This article is published in The Journal of Pathology.The article was published on 1969-02-01. It has received 83 citations till now.

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Patent

Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation

TL;DR: In this article, a method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed, which comprises treating the cell with a cholinergic agonist, which is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock.
Patent

Neural stimulation devices and systems for treatment of chronic inflammation

TL;DR: In this article, a system for treating chronic inflammation may include an implantable micro-stimulator, a wearable charger, and optionally an external controller, which can address several types of stimulation including regular dose delivery.
Journal ArticleDOI

Cytotoxic Drugs in Treatment of Nonmalignant Diseases

TL;DR: The basis for using cytotoxic drugs in inflammatory diseases of uncertain cause is their immunosuppressive properties, and these drugs interrupt nucleic acid and protein synthesis, thereby halting their activity in these diseases.
Patent

Nerve cuff with pocket for leadless stimulator

TL;DR: An extravascular nerve cuff that is configured to hold a leadless, integral, implantable microstimulator is described in this paper, where the nerve cuff can be secured around the nerve such that the electrodes of the device are stably positioned relative to the nerve.
Journal ArticleDOI

Low dose oral methotrexate in rheumatoid arthritis: an uncontrolled trial and review of the literature

TL;DR: Despite the encouraging preliminary results it is unclear whether MTX can prevent erosions or improve long-term function and quality of life in RA, there are still no controlled perspective studies comparing MTX to placebo or other immunosuppressive agents in RA.
References
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Journal ArticleDOI

Nature and mode of action of antilymphocytic antiserum.

TL;DR: The experiments reported here are intended to throw further light on the nature and mode of action of ALS and the sensitivity aroused in CBA mice by grafts of A skin, as measured by the survival time of a second graft transplanted at various intervals after the rejection of a first graft.
Journal ArticleDOI

On the mechanism of cortisone inhibition of connective tissue proliferation

TL;DR: Cortisone was effective by local as well as by general application, similar concentrations producing the same degree of inhibition of connective tissue.
Journal ArticleDOI

Inhibition of the Local Inflammatory Response in Man by Antimetabolites

TL;DR: Observations of the response in ten untreated patients with acute leukemia showed both impaired granulocyte and mononuclear phases of the responded, which was not correlated with alterations in the levels of circulating granulocytes or lymphocytes, nor with the numbers ofgranulocytes entering the inflammatory site.