Journal ArticleDOI
The association between psoriasis, diabetes mellitus, and atherosclerosis in Israel: A case-control study
Jonathan Shapiro,Arnon D. Cohen,Michael David,Emilia Hodak,Gabi Chodik,Anna Viner,Eyal Kremer,Anthony Heymann +7 more
TLDR
This study supports previous reports for an association between psoriasis and atherosclerosis and psOriasis and diabetes and supports selection bias that may occur due to the possibility that reporting of both psor infection and associated illnesses is higher in individuals who are seeking medical care.Abstract:
Background Previous reports demonstrated an association between psoriasis and other diseases including heart failure and diabetes mellitus. Objectives Our aim was to describe the association between psoriasis, diabetes mellitus, and atherosclerosis in Israel. Methods A cross-sectional study was performed utilizing the database of Maccabi Healthcare Services (MHS), a large health provider organization in Israel. Case patients were defined as subjects who were diagnosed with psoriasis. Patients with diabetes and atherosclerosis were identified by using the MHS diabetes and cardiovascular registries, respectively. The control group included MHS enrollees without psoriasis. The proportion of diabetes and atherosclerosis among case and control groups was compared. Chi-square tests were used to compare categorical parameters. Logistic regression models were used for multivariate analyses. Results The study included 46,095 patients with psoriasis (case patients) and 1,579,037 subjects without psoriasis (control patients). The age-adjusted proportion of diabetes was significantly higher in psoriasis patients as compared with the control group (odds ratio [OR] 1.27, 95% confidence interval [CI] 1.1-1.48). The age-adjusted proportion of atherosclerosis was significantly higher in psoriasis patients as compared with the control group (OR 1.28, 95% CI 1.04-1.59). In patients with psoriasis, a multivariate logistic regression model demonstrated an association between diabetes and the multiple use of very potent topical steroids ( P P P Limitations Our study was based on a computerized database. The diagnosis of psoriasis was based on digitally transmitted data. Therefore overestimation (false-positive cases) and underestimation (false-negative cases) of psoriasis patients may exist, thereby being a source for information bias. A second limitation is selection bias that may occur due to the possibility that reporting of both psoriasis and associated illnesses is higher in individuals who are seeking medical care. A third limitation concerns the causal effect between occurrence of psoriasis and atherosclerosis or diabetes. The dataset of MHS records diagnoses only from 1997 and does not record the date of disease onset. Conclusions Our study supports previous reports for an association between psoriasis and atherosclerosis and psoriasis and diabetes. Further study is needed to support this observation.read more
Citations
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Journal ArticleDOI
Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics
Alan Menter,Alice B. Gottlieb,Steven R. Feldman,Abby S. Van Voorhees,Craig L. Leonardi,Kenneth B. Gordon,Mark Lebwohl,John Koo,Craig A. Elmets,Neil J. Korman,Karl R. Beutner,Reva Bhushan +11 more
TL;DR: The classification of psoriasis; associated comorbidities including autoimmune diseases, cardiovascular risk, psychiatric/psychologic issues, and cancer risk; along with assessment tools for skin disease and quality-of-life issues; and the safety and efficacy of the biologic treatments used to treat patients with Psoriasis are discussed.
Journal ArticleDOI
Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 2. Psoriatic arthritis: Overview and guidelines of care for treatment with an emphasis on the biologics
Alice B. Gottlieb,Neil J. Korman,Kenneth B. Gordon,Steven R. Feldman,Mark Lebwohl,John Koo,Abby S. Van Voorhees,Craig A. Elmets,Craig L. Leonardi,Karl R. Beutner,Reva Bhushan,Alan Menter +11 more
TL;DR: An overview of psoriasis including its cardinal clinical features, pathogenesis, prognosis, classification, assessment tools used to evaluate psoriatic arthritis, and the approach to treatment is given.
Journal ArticleDOI
Guidelines of care for the management of psoriasis and psoriatic arthritis: section 4. Guidelines of care for the management and treatment of psoriasis with traditional systemic agents.
Alan Menter,Neil J. Korman,Craig A. Elmets,Steven R. Feldman,Joel M. Gelfand,Kenneth B. Gordon,Alice B. Gottlieb,John Koo,Mark Lebwohl,Henry W. Lim,Abby S. Van Voorhees,Karl R. Beutner,Reva Bhushan +12 more
TL;DR: The efficacy and safety, and recommendations for the use of the 3 most commonly used, and approved, traditional systemic agents: methotrexate, cyclosporine, and acitretin are discussed.
Journal ArticleDOI
Guidelines of care for the management of psoriasis and psoriatic arthritis: section 6. Guidelines of care for the treatment of psoriasis and psoriatic arthritis: case-based presentations and evidence-based conclusions.
Alan Menter,Neil J. Korman,Craig A. Elmets,Steven R. Feldman,Joel M. Gelfand,Kenneth B. Gordon,Alice B. Gottlieb,John Koo,Mark Lebwohl,Craig L. Leonardi,Henry W. Lim,Abby S. Van Voorhees,Karl R. Beutner,Karl R. Beutner,Caitriona Ryan,Reva Bhushan +15 more
TL;DR: The approach to treating patients with psoriasis across the entire spectrum of this fascinating disease from mild to moderate to severe, with and without psoriatic arthritis, is described, based on the 5 prior published guidelines.
Journal ArticleDOI
Association of Psoriasis With Coronary Artery, Cerebrovascular, and Peripheral Vascular Diseases and Mortality
Srjdan Prodanovich,Robert S. Kirsner,Jeffrey D. Kravetz,Fangchao Ma,Lisa Martinez,Daniel G. Federman +5 more
TL;DR: Psoriasis is associated with atherosclerosis and this association applies to coronary artery, cerebrovascular, and peripheral vascular diseases and results in increased mortality.
References
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Journal ArticleDOI
Disease concomitance in psoriasis
Tilo Henseler,Enno Christophers +1 more
TL;DR: Although systemic disorders such as obesity, diabetes, and heart disease may be related to dietary habits and nutritional status, the relative resistance to cutaneous infections together with decreased immune responsiveness suggest a genetically determined selection.
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Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis: Results from an Italian case-control study
Luigi Naldi,Liliane Chatenoud,Dennis Linder,Anna Belloni Fortina,Andrea Peserico,Anna Virgili,Pier Luigi Bruni,Vito Ingordo,Giovanni Lo Scocco,C Solaroli,Donatella Schena,Annalisa Barba,Anna Di Landro,Enrico Pezzarossa,Fabio Arcangeli,Claudia Gianni,Roberto Betti,Paolo Carli,Alessandro Farris,Gian Franco Barabino,Carlo La Vecchia,Carlo La Vecchia +21 more
TL;DR: Risks of psoriasis of recent onset with smoking habits, body mass index (BMI) and stressful life events were consistent with a multiplicative model of risk combination with no significant statistical interaction.
Journal ArticleDOI
Impact of obesity and smoking on psoriasis presentation and management.
Mark D. Herron,Michael Hinckley,Matthew S. Hoffman,Jason Papenfuss,Christopher B. Hansen,Kristina P. Callis,Gerald G. Krueger +6 more
TL;DR: Patients with psoriasis attending the University of Utah Dermatology Clinics were more likely to be obese and to smoke compared with non-psoriatic patients and more likelyto be obese compared with other large cohorts with Psoriasis.
Journal ArticleDOI
Increased risk for cardiovascular mortality in psoriasis inpatients but not in outpatients.
Lotus Mallbris,Olof Akre,Fredrik Granath,Li Yin,Bernt Lindelöf,Anders Ekbom,Mona Ståhle-Bäckdahl +6 more
TL;DR: It is concluded that a diagnosis of psoriasis per se does not appear to increase the risk for cardiovascular mortality, however, severe Psoriasis, here measured as repeated admissions, and early age at first admission, is associated with increasedrisk for cardiovascular death.
Journal ArticleDOI
Diseases Associated with Psoriasis in a General Population of 159,200 Middle-Aged, Urban, Native Swedes
TL;DR: A defined general population of 159,200 male and female native Swedes born in the period of 1911-1940, from an urban catchment area of the then only general hospital, was followed over a decade with regard to inpatient hospitalization for all kinds of diagnoses.