Journal ArticleDOI
The binding of ortho-aminoazotoluene in proliferating tissue
T.A. Lawson,F.K. Dzhioev +1 more
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TLDR
The binding of [3H]ortho-aminoazotoluene to liver DNA, RNA and protein was similar to that in non-hepatectomised mice during the periods of increased DNA synthesis and the second period of increased mitosis.About:
This article is published in Chemico-Biological Interactions.The article was published on 1970-10-01. It has received 14 citations till now. The article focuses on the topics: DNA synthesis & Ligation.read more
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Journal ArticleDOI
In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis.
TL;DR: A comparison of CBI for rat-liver DNA with hepatocarcinogenic potency reveals a surprisingly good quantitative correlation and refineements for a DNA-binding assay are proposed.
Book ChapterDOI
The Repair of DNA Modified by Cytotoxic, Mutagenic, and Carcinogenic Chemicals
TL;DR: This chapter discusses some studies on the interaction of various compounds with cellular DNA and the biochemical and biological consequences of these reactions in a variety of cell systems and focuses attention on DNA as the principal target for a number of chemotherapeutically useful cytotoxic agents and for numerous known carcinogens.
Book ChapterDOI
Chapter 8 – CELL PROLIFERATION AND EXPERIMENTAL LIVER CANCER
TL;DR: There is evidence in a number of cases that cell replication alters neither the metabolism of the carcinogen, nor the nature, extent or persistence of the binding of the activated carcinogen to macromolecules.
Journal ArticleDOI
ICPEMC publication no. 13 the need for biological risk assessment in reaching decisions about carcinogens (MTR07214)
TL;DR: The prudent assumption that carcinogen bioassays in rodents predict for human carcinogenicity is examined and it is suggested that in certain cases, as for example the induction of tumors against a high incidence in controls, or in situations in which high dose toxicity may be a critical factor inThe induction of cancer, the probability that animal bioassay predict for humans may be low.
Journal ArticleDOI
In vivo and in vitro binding of benzene to nucleic acids and proteins of various rat and mouse organs.
TL;DR: labelling of RNA and proteins is higher (1 order of magnitude) than DNA labelling, which is low in many organs, and negligible in lung; no difference between labelling of rat and mouse organs was found.
References
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Journal ArticleDOI
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid
TL;DR: The present study arose from the observation that a more intense colour was sometimes produced if, instead of being heated at 1000 for 10 min., the reaction mixture was allowed to stand overnight at room temperature.
Journal ArticleDOI
A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues.
TL;DR: The methods used at present for the determination of the higher nucleic acids in organs are based on certain color reactions of their carbohydrate components, but if the quantitative estimations of desoxyribonucleic acid and of ribon nucleic acid could be based on phosphorus determinations rather than on color tests of their carbohydrates components, these difficulties might be avoided.
Book ChapterDOI
Regeneration of mammalian liver.
TL;DR: The chapter reviews experimental studies on the homeostatic control of hepatic growth, as exemplified primarily by regeneration in response to partial hepatectomy, with particular attention to the first cycle of cellular growth and division.